Research Article

Relationship between CYP2C19 Polymorphism and Clopidogrel Resistance in Patients with Coronary Heart Disease and Ischemic Stroke in China

Table 2

Comparison of differences in baseline information between CR and non-CR for all participants.

CharacteristicsNon-CR (N = 39)CR (N = 52) value

Age, years#59.46 ± 11.0169.79 ± 11.67<0.001
Height (m)#1.70 ± 0.081.66 ± 0.090.062
Weight (Kg)#68.56 ± 9.6467.79 ± 11.600.736
BMI (Kg/m2)#23.71 ± 2.4324.41 ± 2.890.225
Oxygen saturation (%)91.0 (89.0, 93.0)90.0 (90.0, 92.8)0.827
SBP (mmHg)#126.3 ± 27.2127.4 ± 22.30.837
DBP (mmHg)#74.9 ± 14.973.2 ± 12.50.553
Heart rate#76.5 ± 14.877.1 ± 16.20.854
White blood cell7.32 (5.55, 10.06)7.17 (5.71, 11.33)0.721
Red blood cell4.89 (4.40, 5.54)4.70 (4.25, 5.22)0.342
Hemoglobin#153.2 ± 28.7149.5 ± 20.30.500
Glycosylated hemoglobin5.63 (5.38, 6.19)6.06 (5.52, 7.17)0.005
PT12.0 (11.7, 12.7)11.9 (11.4, 12.5)0.271
APTT28.7 (26.7, 32.3)26.9 (24.3, 31.0)0.008
ALT37.0 (19.0, 82.0)28.5 (19.3, 42.0)0.183
AST48.0 (22.0, 221.0)33.5 (21.3, 109.5)0.195
AST/ALT1.3 (0.9, 3.4)1.2 (0.8, 2.3)0.431
Urea nitrogen5.91 (4.97, 10.04)6.28 (5.25, 7.99)0.745
Creatinine83.0 (67.0, 96.0)84.0 (67.3, 92.8)0.591
Glomerular filtration rate (mL/min × 1.73 m2)#80.7 ± 28.376.0 ± 22.70.389
Albumin38.2 (34.7, 41.1)37.8 (34.9, 39.7)0.510
Total cholesterol (mmol/L)#4.00 ± 1.224.17 ± 1.050.478
Triglyceride1.32 (0.90, 1.97)1.59 (0.90, 2.38)0.432
TSH1.19 (0.54, 2.68)1.68 (1.20, 2.89)0.156

Sex, n (%)0.022
 Male32 (82.1)31 (59.6)
 Female7 (17.9)21 (40.4)

Aspirin resistance, n (%)<0.001
 No28 (71.8)14 (26.9)
 Yes11 (28.2)38 (73.1)

Smoking history, n (%)0.328
 No20 (51.3)32 (61.5)
 Yes19 (48.7)20 (38.5)

Coronary heart disease type, n (%)0.041
 STEMI19 (48.7)23 (44.2)
 NSTEMI8 (20.5)4 (7.7)
 SAP2 (5.1)13 (25.0)
 UA10 (25.6)12 (23.1)

Hypertension, n (%)0.157
 No16 (41.0)14 (26.9)
 Yes23 (59.0)38 (73.1)

Diabetes, n (%)0.004
 No26 (66.7)19 (36.5)
 Yes13 (33.3)33 (63.5)

Stroke, n (%)0.899
 No25 (64.1)34 (65.4)
 Yes14 (35.9)18 (34.6)

Hyperlipidaemia, n (%)0.355
 No21 (53.8)33 (63.5)
 Yes18 (46.2)19 (36.5)

CYP2C192, n (%)0.412
 GG24 (61.5)37 (71.2)
 GA11 (28.2)13 (25.0)
 AA4 (10.3)2 (3.8)

CYP2C192, n (%)0.334
 GG24 (61.5)37 (71.2)
 GA + AA15 (38.5)15 (28.8)

CYP2C193, n (%)0.387
 GG22 (56.4)22 (42.3)
 GA10 (25.6)16 (30.8)
 AA7 (17.9)14 (26.9)

CYP2C193, n (%)0.183
 GG22 (56.4)22 (42.3)
 GA + AA17 (43.6)30 (57.7)

CYP2C1917, n (%)0.532
 GG23 (59.0)34 (65.4)
 GA16 (41.0)18 (34.6)