Research Article

Relationship between CYP2C19 Polymorphism and Clopidogrel Resistance in Patients with Coronary Heart Disease and Ischemic Stroke in China

Table 3

Comparison of differences in baseline information between CR and non-CR for Han populations.

CharacteristicsNon-CR (N = 27)CR (N = 40) value

Age, years#59.33 ± 10.4870.48 ± 11.38<0.001
Height (m)#1.70 ± 0.081.67 ± 0.090.115
Weight (Kg)#69.04 ± 9.9368.78 ± 11.860.925
BMI (Kg/m2)#23.60 ± 2.1324.59 ± 3.040.151
Oxygen saturation (%)91.0 (89.0, 93.0)90.5 (89.3, 93.0)0.892
SBP (mmHg)#129.6 ± 28.1128.1 ± 17.70.809
DBP (mmHg)#75.0 ± 14.173.2 ± 11.00.549
Heart rate#77.7 ± 14.279.1 ± 15.70.699
White blood cell7.17 (5.55, 10.53)6.93 (5.48, 11.06)0.898
Red blood cell5.10 (4.55, 5.55)4.60 (4.25, 5.26)0.120
Hemoglobin#158.5 ± 22.1149.7 ± 20.60.098
Glycosylated hemoglobin5.57 (5.38, 5.97)6.09 (5.49, 7.24)0.009
PT11.9 (11.6, 12.7)11.7 (11.2, 12.5)0.169
APTT27.9 (26.7, 30.9)26.5 (24.5, 30.0)0.031
ALT33.0 (20.0, 70.0)27.0 (18.3, 39.5)0.125
AST60.0 (22.0, 209.0)31.0 (20.0, 121.5)0.179
AST/ALT1.4 (1.0, 3.4)1.2 (0.8, 2.4)0.315
Urea nitrogen5.41 (4.86, 7.54)6.11 (5.25, 7.63)0.201
Creatinine78.0 (67.0, 90.0)84.5 (67.0, 93.0)0.908
Glomerular filtration rate (mL/min × 1.73 m2)#87.4 ± 28.375.9 ± 21.50.064
Albumin38.6 (36.1, 41.4)37.8 (35.2, 40.0)0.457
Total cholesterol (mmol/L)#4.07 ± 1.024.16 ± 1.040.731
Triglyceride1.29 (0.90, 1.97)1.77 (0.90, 2.51)0.315
TSH1.79 (0.66, 2.65)1.62 (1.15, 2.81)0.498

Sex, n (%)0.010
 Male23 (85.2)22 (55.0)
 Female4 (14.8)18 (45.0)

Aspirin resistance, n (%)<0.001
 No20 (74.1)10 (25.0)
 Yes7 (25.9)30 (75.0)

Smoking history, n (%)0.065
 No10 (37.0)24 (60.0)
 Yes17 (63.0)16 (40.0)

Coronary heart disease type, n (%)0.206
 STEMI14 (51.9)17 (42.5)
 NSTEMI5 (18.5)3 (7.5)
 SAP2 (7.4)9 (22.5)
 UA6 (22.2)11 (27.5)

Hypertension, n (%)0.110
 No11 (40.7)9 (22.5)
 Yes16 (59.3)31 (77.5)

Diabetes, n (%)0.003
 No20 (74.1)15 (37.5)
 Yes7 (25.9)25 (62.5)

Stroke, n (%)0.969
 No17 (63.0)25 (62.5)
 Yes10 (37.0)15 (37.5)

Hyperlipidaemia, n (%)0.570
 No15 (55.6)25 (62.5)
 Yes12 (44.4)15 (37.5)

CYP2C192, n (%)0.333
 GG16 (59.3)29 (72.5)
 GA7 (25.9)9 (22.5)
 AA4 (14.8)2 (5.0)

CYP2C192, n (%)0.258
 GG16 (59.3)29 (72.5)
 GA + AA11 (40.7)11 (27.5)

CYP2C193, n (%)0.216
 GG17 (63.0)17 (42.5)
 GA6 (22.2)11 (27.5)
 AA4 (14.8)12 (30.0)

CYP2C193, n (%)0.100
 GG17 (63.0)17 (42.5)
 GA + AA10 (37.0)23 (57.5)

CYP2C1917, n (%)0.888
 GG18 (66.7)26 (65.0)
 GA9 (33.3)14 (35.0)