Research Article

Relationship between CYP2C19 Polymorphism and Clopidogrel Resistance in Patients with Coronary Heart Disease and Ischemic Stroke in China

Table 4

Comparison of differences in baseline information between CR and non-CR for Tibetan populations.

CharacteristicsNon-CR (N = 12)CR (N = 12) value

Age, years#59.75 ± 12.6367.50 ± 12.820.150
Height (m)#1.68 ± 0.081.64 ± 0.080.227
Weight (Kg)#67.50 ± 9.2664.50 ± 10.490.466
BMI (Kg/m2)#23.97 ± 3.1123.84 ± 2.310.911
Oxygen saturation (%)90.5 (89.0, 92.8)90.0 (90.0, 92.0)0.630
SBP (mmHg)#119.1 ± 24.6125.2 ± 34.40.623
DBP (mmHg)#74.8 ± 17.373.4 ± 17.10.851
Heart rate#73.8 ± 16.470.3 ± 16.50.607
White blood cell7.35 (5.36, 9.55)9.08 (6.86, 15.20)0.266
Red blood cell4.55 (3.78, 5.49)4.79 (4.19, 5.19)0.731
Hemoglobin#141.1 ± 38.3149.0 ± 20.10.533
Glycosylated hemoglobin5.69 (5.26, 7.04)6.01 (5.81, 6.91)0.291
PT12.1 (11.9, 13.3)12.3 (11.9, 13.5)0.799
APTT31.8 (27.2, 35.0)29.4 (23.6, 32.0)0.114
ALT45.0 (12.0, 134.8)35.5 (20.3, 51.8)0.887
AST43.0 (20.0, 771.8)44.5 (23.3, 106.0)0.843
AST/ALT1.0 (0.7, 4.7)1.1 (0.6, 2.1)0.887
Urea nitrogen8.56 (5.99, 13.66)7.16 (5.13, 8.80)0.443
Creatinine93.5 (76.3, 127.5)82.5 (72.8, 88.5)0.319
Glomerular filtration rate (mL/min × 1.73 m2)#65.5 ± 22.676.4 ± 27.30.297
Albumin37.7 (32.6, 41.0)36.2 (33.2, 38.3)0.833
Total cholesterol (mmol/L)#3.84 ± 1.624.20 ± 1.100.528
Triglyceride1.38 (0.92, 1.95)1.16 (0.89, 2.09)0.799
TSH1.12 (0.36, 2.94)2.04 (1.26, 2.90)0.211

Sex, n (%)1.000
 Male9 (75.0)9 (75.0)
 Female3 (25.0)3 (25.0)

Aspirin resistance, n (%)0.102
 No8 (66.7)4 (33.3)
 Yes4 (33.3)8 (66.7)

Smoking history, n (%)0.342
 No10 (83.3)8 (66.7)
 Yes2 (16.7)4 (33.3)

Coronary heart disease type, n (%)0.618
 STEMI5 (41.7)6 (50.0)
 NSTEMI3 (25.0)1 (8.3)
 SAP0 (0.0)4 (33.3)
 UA4 (33.3)1 (8.3)

Hypertension, n (%)1.000
 No5 (41.7)5 (41.7)
 Yes7 (58.3)7 (58.3)

Diabetes, n (%)0.408
 No6 (50.0)4 (33.3)
 Yes6 (50.0)8 (66.7)

Stroke, n (%)0.653
 No8 (66.7)9 (75.0)
 Yes4 (33.3)3 (25.0)

Hyperlipidaemia, n (%)0.408
 No6 (50.0)8 (66.7)
 Yes6 (50.0)4 (33.3)

CYP2C192, n (%)1.000
 GG8 (66.7)8 (66.7)
 GA4 (33.3)4 (33.3)

CYP2C193, n (%)0.855
 GG5 (41.7)5 (41.7)
 GA4 (33.3)5 (41.7)
 AA3 (25.0)2 (16.7)

CYP2C193, n (%)1.000
 GG5 (41.7)5 (41.7)
 GA + AA7 (58.3)7 (58.3)

CYP2C1917, n (%)0.219
 GG5 (41.7)8 (66.7)
 GA7 (58.3)4 (33.3)