Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis
Table 2
Genetic models and SNP-592C/A in the IL-10 gene in cervical cancer.
Study
N
Cases/control
Models
Effect estimate/statistical
Bonferroni
Heterogeneity
OR (95% CI)
value
α
Sig
I2 (%)
All studies
11
4187/3311
Recessive
1.30 (1.14–1.49)
0.0001
0.016
Yes
28
0.18
Dominant
1.36 (1.09–1.70)
0.006
0.016
Yes
66
<0.05
Additive
1.25 (1.09–1.44)
0.001
0.025
Yes
66
<0.05
Caucasian
4
2221/1240
Recessive
1.50 (1.12–2.00)
0.006
0.016
Yes
39
0.18
Dominant
1.57 (1.03–2.40)
0.04
0.016
No
84
<0.05
Additive
1.15 (1.15–1.46)
<0.0001
0.025
Yes
81
<0.05
Asian
7
1966/2071
Recessive
1.25 (1.07–1.46)
0.004
0.016
Yes
24
0.25
Dominant
1.26 (1.09–1.46)
0.002
0.016
Yes
42
0.11
Additive
1.19 (1.08–1.30)
0.0002
0.035
Yes
50
0.06
N: number; : value OR; : value of heterogeneity; I2: inconsistency; recessive model: AA vs. CC + CA; dominant model: AA + CA vs. CC; additive model: A vs. C; = fixed-effect model, = random-effect model; N = number; α = Bonferroni correction; Sig = Bonferroni significance.
