Effects of Genetic Variants in the Nicotine Metabolism Pathway on Smoking Cessation

Table 2

Genetic variants investigated in this study.

Gene	SNP ID	Chr	Chr position (GRCh38.p2)	Alleles (major/minor)	MAF (case/control)	HWE P^a
CYP2B6	rs3760657	19	40989528	A/G	0.197/0.241	0.242
	rs4802101	19	40990556	C/T	0.366/.0348	0.951
	rs707265	19	41018182	G/A	0.391/0.378	0.821
CYP2D6	rs1135840	22	42126611	G/C	0.326/0.306
	rs16947	22	42127941	G/A	0.176/0.187	0.004
	rs1081003	22	42129754	G/A	0.484/0.484	0.370
	rs1065852	22	42130692	G/A	0.467/0.499	0.258
AOX1	rs2072034	2	200585011	C/G	0.393/0.435	0.114
	rs10931910	2	200659013	G/A	0.136/0.130	0.375
	rs3731722	2	200669666	A/G	0.088/0.078	0.508
FMO3	rs1736555	1	171089111	G/A	0.375/0.413	0.358
	rs10911192	1	171102742	A/C	0.452/0.429	0.914
	rs2266782	1	171107825	G/A	0.225/0.193	0.271
	rs1736557	1	171110939	G/A	0.209/0.212	0.616
	rs2075992	1	171111344	T/C	0.349/0.370	0.370
	rs909529	1	171113756	C/T	0.237/0.216	0.354
	rs909530	1	171114034	C/T	0.401/0.374	0.957
	rs2266780	1	171114102	A/G	0.192/0.181	0.331
	rs909531	1	171114397	T/C	0.196/0.186	0.141
UGT1A4	rs3806594	2	233717244	T/C	0.174/0.191	0.107
	rs3732217	2	233719624	G/A	0.167/0.191	0.107
UGT2B10	rs2942857	4	68822269	A/C	0.090/0.097	0.042
	rs11726322	4	68825803	G/C	0.183/0.151	0.233
	rs4694358	4	68830930	T/C	0.135/0.120	0.011
UGT1A9	rs17864684	2	233670717	G/A	0.132/0.146	0.144
	rs7349250	2	233673274	A/G	0.231/0.217	0.173
	rs2602379	2	233674416	G/A	0.464/0.438	0.450
	rs1604144	2	233697189	C/T	0.238/0.254	0.533
	rs12988520	2	233698748	A/C	0.278/0.268	0.154
	rs2885295	2	233711220	T/A	0.175/0.187	0.032
	rs871514	2	233719883	T/C	0.200/0.167
	rs10178992	2	233749231	T/A	0.150/0.125	0.502
	rs10929303	2	233772770	C/T	0.145/0.132	0.638
UGT2B7	rs12233719	4	69096731	G/T	0.175/0.138	0.012
	rs7439366	4	69098620	C/T	0.362/0.384	0.800
	rs12512526	4	69100700	C/T	0.360/0.386	0.606
	rs4292394	4	69107231	G/C	0.361/0.389	0.490
UGT2B15	rs3100	4	68646936	G/A	0.203/0.144	0.694
	rs4148269	4	68647129	T/G	0.194/0.165	0.537
	rs9994887	4	68671757	A/G	0.493/0.483	0.612
	rs13112099	4	68672015	T/G	0.320/0.332
CYP2A6	CYP2A6 deleted ( 4)	19	Whole gene	Non  4/4	0.249/0.174

MAF: minor allele frequency; HWE: Hardy-Weinberg Equilibrium. ^aThe HWE P value shows the Hardy-Weinberg Equilibrium test in control subjects.