Effects of Genetic Variants in the Nicotine Metabolism Pathway on Smoking Cessation

Table 4

Association between the gene scores and smoking cessation.

Gene	Successful quitters (n = 363)	Failed quitters (n = 345)	OR (95% CI)		OR (95% CI)^a	^a
CYP2B6	0.394 ± 0.598	0.485 ± 0.597	0.776 (0.605–0.994)	0.045	0.729 (0.563–0.944)	0.016
CYP2D6	1.344 ± 0.326	1.293 ± 0.327	1.618 (1.021–2.562)	0.040	1.678 (1.038–2.713)	0.035
AOX1	1.278 ± 1.246	1.445 ± 1.286	0.901 (0.802–1.013)	0.081	0.903 (0.801–1.019)	0.098
FMO3	0.343 ± 0.668	0.206 ± 0.598	1.410 (1.109–1.792)	0.005	1.405 (1.096–1.799)	0.007
UGT1A4	0.256 ± 0.947	0.383 ± 0.843	0.848 (0.710–1.013)	0.069	0.873 (0.728–1.047)	0.144
UGT2B10	0.353 ± 0.436	0.290 ± 0.387	1.447 (1.010–2.073)	0.044	1.489 (1.026–2.159)	0.036
UGT1A9	16.767 ± 22.785	11.698 ± 20.891	1.011 (1.004–1.018)	0.002	1.011 (1.004–1.019)	0.002
UGT2B7	0.228 ± 0.784	0.107 ± 0.701	1.245 (1.020–1.520)	0.032	1.237 (1.006–1.521)	0.044
UGT2B15	0.546 ± 0.720	0.378 ± 0.638	1.444 (1.155–1.807)	0.001	1.466 (1.162–1.851)	0.001
Total	0.703 ± 0.479	0.451 ± 0.440	3.311 (2.342–4.679)		3.411 (2.382–4.884)

Values are expressed as mean ± SD. ^a indicates adjustment for age, occupation, education level, marital status, age of smoking onset, and pack-year.