circRNA_101277 Influences Cisplatin Resistance of Colorectal Cancer Cells by Modulating the miR-370/IL-6 Axis

Figure 3

circRNA_101277 sequesters miR‐370. (a) Putative miR-370 binding sites within circRNA_101277. (b) Relative circRNA_101277‐WT luciferase activity was decreased by miR‐370 mimics in CRC cells. (c) qRT-PCR was used to assess miR-370 expression. (d) CRC tissues exhibited marked miR-370 downregulation relative to normal tissues. (e) miR-370 expression was negatively correlated with that of circRNA_101277 in CRC tissues. (f) An MTT assay was used to assess the cisplatin IC50 value in the indicated cells. ^∗p < 0.05.

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