circRNA_101277 Influences Cisplatin Resistance of Colorectal Cancer Cells by Modulating the miR-370/IL-6 Axis

Figure 4

circRNA_101277 modulates the miR-370/IL-6 axis to enhance cisplatin resistance. (a) Putative miR‐370 binding sites within the IL-6 3′‐UTR. (b) miR-370 mimics decreased the luciferase activity of the IL‐6-WT reporter in CRC cells. The expression of IL-6 was measured via qRT-PCR (c) and ELISA (d). (e) IL-6 expression was markedly elevated in CRC tissues relative to healthy control tissue. (f) The expression of IL-6 in CRC tissues was negatively correlated with that of miR-370. (g) The expression of IL-6 was positively correlated with that of circRNA_101277 in CRC tissues. (h) An MTT assay was used to assess the cisplatin IC50 value in the indicated cells. ^∗p < 0.05.

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