TPX2 Serves as a Cancer Susceptibility Gene and Is Closely Associated with the Poor Prognosis of Endometrial Cancer

Figure 4

CNV analysis and GSEA of TPX2 in EC patients. (a) The circos of the human genome illustrating the chromosomal structure and localization of TPX2 CNVs in endometrial carcinoma. The outer most layer denotesthe chromosome model while the next layer indicates CNVs (blue dot: deletion; black dot: amplification). (b) TPX2 copy number gain and the corresponding expression levels of TPX2 mRNA (blue: copy number normal; green: single gain; red: amplification). (c) The effect of TPX2 copy number gain (including single gain and amplification) on OS in EC patients. (d) The effect of TPX2 copy number gain on OS of EC patients based on the FIGO stage. (e) Gene sets enriched in the group with high TPX2 expression. NES: normalized enrichment score.

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