Positive Expression of Retinol-Binding Protein 4 Is Related to the Malignant Clinical Features Leading to Poor Prognosis of Glioblastoma

Figure 1

Transcription, methylation, and protein expression of RBP4 in GBM. (a) The mRNA level of RBP4 in GBM tissues was retrieved from TCGA datasets and divided into low level or high level according to the FPKM (fragments per kilobase of transcript per million). Then overall survival (OS) curves were plotted using Kaplan–Meier method and compared by the log-rank test, which revealed that higher mRNA level of RBP4 was correlated with poorer OS . (b) The methylation of RBP4 in GBM tissues was obtained from MethSurv web tool (https://biit.cs.ut.ee/methsurv/) and subgrouped as lower methylation level and higher methylation level. Survival curves showed that patients with lower RBP4 methylation level had poorer prognosis . (c) Representative negative protein expression of RBP4 in GBM tissues. Magnification: 400X. (d) Representative positive protein expression of RBP4 in GBM tissues. Magnification: 400X.

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