Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz

Table 1

Polymorphism details and primers.

rs	Allele	Nucleotide change	Amino acid change	Length of PCR products			Type		Primer sequences (5’ > 3′)
rs3745274	CYP2B66	(516G > T)	Gln172His	FU + RU = 600	FU + RN = 353	FU + RM = 353	Missense	FU	TGTGTTGCCTGGGTCTAAATC
								RU	CTGATTCTTCACATGTCTGCGT
								RN	AGCAGATGATGTTGGCGGTAATGGAC
								RM	TGATGTTGGCGGTAATGGAA
rs2279343	CYP2B64	(785A > G)	Lys262Arg	FU + RU = 734	FU + RN = 256	FU + RM = 256	Missense	FU	GTTCCCATGGAGGGATTGGG
								RU	CTCTACACATCCAACCGCGTA
								RN	GAGCAGGTAGGTGTCGATGAGGTCCT
								RM	GTAGGTGTCGATGAGGTCCC
rs3211371	CYP2B65	(1459C > T)	Arg487Cys	FU + RU = 381	FU + RN = 206	RU + FM = 209	Missense	FU	CACACTGGTGACCTTCTGTGT
								RU	CCTGCACTCACTTGCAATGT
								RN	CGCTTCCTGCCCCGCTGAAGGGGCTG
								FM	CAAAATACCCCCAACATACCAGATCT