Research Article

Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz

Table 3

Allele frequencies in Iranian populations.

CYP2B66 (516G > T)
EthnicityGTχ2 statistic value
Total (n = 147)58.50 (52.64, 64.19)41.50 (35.81, 47.36)
Kurd (n = 26)40.38 (27.01, 54.90)59.62 (45.10, 72.99)5.88080.015
Turk (n = 52)61.54 (51.49, 70.91)38.46 (29.09, 48.51)0.29320.588
Fars (n = 69)60.14 (51.47, 68.38)39.86 (31.62, 48.53)0.10460.746

CYP2B64 (785A > G)
EthnicityAGχ2 statistic value
Total (n = 147)62.59 (56.78, 68.13)37.41 (31.87, 43.22)
Kurd (n = 26)53.85 (39.47, 67.77)46.15 (32.23, 60.53)1.4220.233
Turk (n = 52)55.77 (45.70, 65.50)44.23 (34.50, 54.30)1.49750.221
Fars (n = 69)71.01 (62.69, 78.42)28.98 (21.58, 37.31)2.94420.086

CYP2B65 (1459C > T)
EthnicityCTχ2 statistic value
Total (n = 147)75.51 (70.18, 80.32)24.49 (19.68, 29.82)
Kurd (n = 26)53.85 (39.47, 67.77)46.15 (32.23, 60.53)10.34420.0012
Turk (n = 52)84.62 (76.22, 90.94)15.38 (9.06, 23.78)3.69830.054
Fars (n = 69)76.81 (68.87,83.57)23.19 (16.43, 31.13)0.0870.768

value for χ2 test is statistically significant ( value <0.05).