How Various Drug Delivery Methods Could Aid in the Translation of Genome Prime Editing Technologies

Table 1

Nanomedicine systems for prime editing delivery.

Carrier	Advantages	Disadvantages
Liposomes	Versatile size control	Potential cytotoxicity
	Easy to design and engineer	Liposomal instability
	FDA clearance	Phagocytic clearance
Micelles	System simplicity	Lack of firm-targeting capability
	Cargo stability	Postsynthesis alteration may lose desired properties
		Innate biomarkers leading to robust cytotoxicity
Exosomes
Polymer-based systems	A wide range of properties	Potential incapacitation
	Easy to incorporate a specific targeting method	Loss of protein function
Dendrimers	Easy penetration across difficult in vivo barriers	Cargo loading limitation
Rigid nanoparticles	Various fabrication techniques	Limited cargo production
		Potential surface dissolution