An Integrative Multi-Omics Analysis Based on Nomogram for Predicting Prostate Cancer Bone Metastasis Incidence

Figure 2

SNV comparisons in patients at a low and high risk of bone metastasis. (a) Mutational landscape profile for prostate cancer patient samples, with the waterfall plot being used to show mutational information for each gene, while colors with specific annotations along the bottom of the plot denote specific types of mutations. Mutational burden is shown in a bar plot above the legend. MB, metastasis of bone. (b) TMB value for the LRBM and HRBM cohorts. Violin plots represent TMB values as dots, with a box plot being present within this violin plot. , , ; two-sided Mann–Whitney U test. (c) Differentially mutated genes were compared between the LRBM and HRBM cohorts with the “mafCompare” function in the R “maftools” package. , , . (d-e) Coincident and exclusive associations among mutated genes within the (d) LRBM and (e) HRBM cohorts.

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