An Integrative Multi-Omics Analysis Based on Nomogram for Predicting Prostate Cancer Bone Metastasis Incidence

Figure 3

Comparisons of CNV and gene fusion frequencies in the HRBM and LRBM cohorts. (a) CNVs with different mutational frequencies in the LRBM and HRBM patient cohorts, with the inner circle presenting a scatter plot of the 676 CNVs that were differentially frequent in these two cohorts, and the outer circle corresponding to the locations of these genes on specific chromosomes. Those genes harboring CNVs that were also significantly differentially expressed between these two cohorts are marked within the circle. (b-c) GO (b) and KEGG (c) analyses of genes containing CNVs at different frequencies in the LRBM and HRBM cohorts, with enriched terms being shown on the left and bar plots on the right corresponding to the number of genes associated with the indicated term. Bar coloration is based on the value for the corresponding term. (d) Frequencies of TMPRSS2-ERG gene fusions in the LRBM and HRBM cohorts, with the y-axis corresponding to the TMPRSS2-ERG gene fusion proportion. (e) Frequencies of gene fusions in the LRBM and HRBM cohorts. Violin plots show gene fusion frequencies in individual samples as dots, with boxplots being drawn within violin plots. , , ; two-sided Mann–Whitney U test.

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