Artificial Selection Drives SNPs of Olfactory Receptor Genes into Different Working Traits in Labrador Retrievers

Table 1

Characteristics of the analyzed SNPs.

SNP	Amino acid variant	Domain	MAF
OR0006:c.524 G > T	p.R175L	EC2	<0.01
OR0007:c.331T>C	p.F111L	TM3	0.50
OR0007:c.430 G > A	p.G144S	IC2	0.50
OR0007:c.508 G > A	p.V170M	TM4	0.01
OR0007:c.691 G > C	p.V231L	TM5	0.38
OR0007:c.730 T >C	p.W244R	TM6	0.39
OR0007:c.793 G > C	p.V265L	TM6	0.41
OR0007:c.829 C >T	p.P277S	EC3	0.40
OR0007:c.830 C >T	p.P277L	EC3	0.40
OR16C11:c.294 G > A	p.Q98Q	TM2	0.03
OR16C11:c.368 C >A	p.A123D	EC1	0.12
OR16C11:c.391 A >G	p.T131A	EC1	0.01
OR16C11:c.632del	I212Y Ter2	TM4	—
DOPRX09:c.479 G > A	p.S160N	EC2	0.49
DOPRX09:c.481 T >G	p.S161A	EC2	0.49
DOPRX09:c.486 T >G	p.F162L	TM5	0.49
DOPRX09:c.889 G > A	p.V263I	C	0.03
OR08G02:c.756 G > T	p.G252G	N/A	—
OR7215:c.251 C >T	P.84L	TM2	0.36
OR7215:c.272ins- > TCTTCC	p.C91FFR	EC1	—
OR7215:c.273ins-> CTTC/CTTCCA	p.C91CFX91CFH	EC1	0.25
OR7215:c.286 G > A	p.G96S	EC1	0.02
OR7215:c.299 A >G	p.Y100C	TM3	0.21
OR7215:c.339 G > A	p.M113I	TM3	0.14
OR7215:c.398delTGCGCTA > -	—	TM4	0.11
OR7215:c.413 G > A	R138H	TM4	0.04
OR7215:c.578 A >T	N193I	TM5	—
OR04B06:c.215 T >G	L72 R	TM2	—
OR04B06:c.394 A >G	A132 T	TM4	—
OR04B06:c.411 A >T	F137 L	TM4	—

Asterisks marked out the breed-specific SNPs. No asterisks meant that the SNPs could be found in other dog breeds besides Labs. MAF: minor allele frequency.