Research Article
Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics
Table 2
Genotype and allele frequencies of ET-1 rs5370 polymorphism.
| Group | Control (%) | Case (%) | a | OR | 95% CI LL | 95% CI UL |
| Genotype | TT | 17 (8.7) | 115 (65.0) | <0.001 | 62.574 | 30.31 | 129.179 | GT | 31 (15.8) | 46 (26.0) | 13.726 | 6.898 | 27.313 | GG | 148 (75.5) | 16 (9.0) | Ref | | |
| Allele | | | | | | | | G | 327 (83.4) | 78 (22) | <0.001 | Ref 17.801 | 12.344 | 25.671 | T | 65 (16.6) | 276 (78) | DOM | TT + GT | 48 (24.5) | 161 (91.00) | <0.001 | | | |
| RES | GG + GT | 179 (91.3) | 62 (35.0) | <0.001 | | | | Post hoc test | Χ2 | valuea | | | | | GG vs. GT | 30.8 | 0.00001 | | | | | GG vs. TT | 120.65 | 0.00001 | | | | | GT vs. TT | 31.672 | 0.00001 | | | | |
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Note: HOM MT = Homozygous mutant; HET = heterozygous; WT = wild type; DOM = dominant; RES = recessive. aChi-square test.
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