Research Article
Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics
Table 3
Genotype and allele frequencies of ECE rs212526 polymorphism.
| Group | Control (%) | Case (%) | a | OR | 95% CI LL | 95% CI UL |
| Genotype | CC | 12 (6.1) | 19 (10.7) | <0.001 | 2.274 | 1.063 | 4.863 | CT | 16 (8.2) | 41 (23.2) | 3.679 | 1.971 | 6.868 | TT | 168 (85.7) | 117 (66.1) | Ref | | |
| Allele | | | | | | | | C | 40 (10.2) | 79 (23.3) | <0.001 | 2.528 | 1.675 | 3.816 | T | 352 (89.8) | 275 (77.7) | Ref | | | DOM | CC + CT | 28 (14.3) | 60 (33.9) | <0.001 | | | |
| RES | TT + CT | 184 (93.9) | 158 (89.3) | <0.001 | | | | Post hoc test | Χ2 | valuea | | | | | CC vs. CT | 0.811 | 0.36 | | | | | CC vs. TT | 8.6 | 0.0033 | | | | | CT vs. TT | 10.156 | 0.0014 | | | | |
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Note: HOM MT = Homozygous mutant; HET = heterozygous; WT = wild type; DOM = dominant; RES = recessive. aChi-square test.
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