Research Article
Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics
Table 4
Clinical and biochemical characteristics according to genotypes of ET-1 rs5370 gene polymorphism.
| Parameter | Control (mean ± SD) | Case (mean ± SD) | TT | GT | GG | a | TT | GT | GG | a |
| Age | 36.41 ± 9.36 | 39.06 ± 9.64 | 40.35 ± 8.74 | 0.124 | 55.25 ± 8.37 | 56.33 ± 10 | 57.55 ± 9.5 | 0.565 | BMI | 22.71 ± 2.77 | 26.9 ± 5.63 | 25.12 ± 4.22 | <0.001 | 23.81 ± 1.78 | 28.03 ± 4.17 | 29.76 ± 4.62 | <0.001 | WHR | 0.92 ± 0.15 | 0.9 ± 0.16 | 0.88 ± 0.06 | 0.583 | 0.83 ± 0.06 | 0.91 ± 0.06 | 0.9 ± 0.11 | 0.016 | FPG | 5.39 ± 1.21 | 5.96 ± 1.92 | 5.68 ± 1.65 | 0.117 | 5.33 ± 2.98 | 6.22 ± 1.6 | 6.87 ± 2.56 | 0.041 | HBA1C | 2.35 ± 2.78 | 4.91 ± 2.67 | 2.27 ± 3.23 | <0.001 | 6.29 ± 1.57 | 6.02 ± 1.44 | 6.69 ± 2.04 | 0.115 | SBP | 119.98 ± 9.64 | 125.16 ± 9.57 | 128.29 ± 12.58 | <0.001 | 153.19 ± 10.02 | 159.15 ± 12.77 | 156.37 ± 12.06 | 0.194 | DBP | 77.45 ± 7.42 | 80.19 ± 7.34 | 81.29 ± 6.66 | 0.035 | 93.88 ± 5.43 | 95.8 ± 6.09 | 94.05 ± 5.75 | 0.207 | CHOL | 4.88 ± 0.96 | 4.56 ± 0.87 | 4.95 ± 0.83 | <0.001 | 4.65 ± 0.95 | 4.94 ± 1.14 | 5.14 ± 1.1 | 0.188 | LDL | 2.62 ± 1 | 2.61 ± 0.73 | 2.88 ± 0.86 | <0.001 | 2.57 ± 0.53 | 2.65 ± 0.92 | 2.99 ± 0.89 | 0.033 | HDL | 1.1 ± 0.36 | 1.16 ± 0.32 | 1.02 ± 0.36 | 0.395 | 1.16 ± 0.31 | 1.3 ± 0.46 | 1.24 ± 0.87 | 0.809 | TG | 1.51 ± 0.66 | 1.27 ± 0.49 | 1.48 ± 0.82 | 0.173 | 1.97 ± 1.08 | 1.65 ± 0.84 | 1.92 ± 1.04 | 0.279 |
|
|
Note: SD = Standard deviation; BMI = body mass index; WHR = waist-to-hip ratio; FPG = fasting plasma glucose; HbA1c = hemoglobin A1c; SBP = systolic blood pressure; DBP = diastolic blood pressure; Chol = cholesterol; LDL = low-density lipid; HDL = High-density lipid; TG = triglyceride. aOne-way ANOVA.
|