Research Article
Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics
Table 5
Clinical and biochemical characteristics according to genotypes of ECE rs212526 gene polymorphism.
| Parameter | Control (mean ± SD) | Case (mean ± SD) | CC | CT | TT | a | CC | CT | TT | a |
| Age | 33.58 ± 4.76 | 42.56 ± 11.4 | 36.92 ± 9.3 | 0.028 | 58 ± 4.68 | 57.32 ± 9.39 | 56.76 ± 10.16 | 0.85 | BMI | 22 ± 1.36 | 24.74 ± 4.64 | 23.59 ± 3.84 | 0.174 | 31.66 ± 4.41 | 28.75 ± 4.88 | 28.31 ± 4.47 | 0.014 | WHR | 0.86 ± 0.08 | 1.03 ± 0.27 | 0.9 ± 0.13 | 0.002 | 0.86 ± 0.23 | 0.91 ± 0.06 | 0.9 ± 0.06 | 0.24 | FPG | 5.19 ± 0.91 | 5.75 ± 1.16 | 5.51 ± 1.44 | 0.59 | 7.71 ± 3.4 | 6.65 ± 2.49 | 6.34 ± 2.19 | 0.104 | HbA1c | 1.04 ± 2.33 | 3.37 ± 3.11 | 2.79 ± 2.93 | 0.091 | 6.26 ± 3.2 | 6.92 ± 1.94 | 6.37 ± 1.53 | 0.248 | SBP | 114.67 ± 10.75 | 121.44 ± 10.6 | 122.02 ± 10.06 | 0.055 | 156.53 ± 9.77 | 157.88 ± 12.09 | 156.48 ± 12.56 | 0.814 | DBP | 72.58 ± 5.81 | 77.13 ± 7.24 | 78.73 ± 7.41 | 0.017 | 92.42 ± 5.95 | 95.95 ± 5.7 | 94.33 ± 5.78 | 0.082 | Chol | 5.14 ± 1.04 | 4.73 ± 1.32 | 4.82 ± 0.89 | 0.468 | 4.95 ± 1.02 | 5.11 ± 1.25 | 5.04 ± 1.07 | 0.871 | LDL | 3.15 ± 0.88 | 2.34 ± 0.91 | 2.63 ± 0.95 | 0.074 | 2.76 ± 0.83 | 2.75 ± 0.98 | 2.92 ± 0.86 | 0.492 | HDL | 1.16 ± 0.29 | 1.04 ± 0.41 | 1.1 ± 0.35 | 0.664 | 1.28 ± 0.4 | 1.19 ± 0.35 | 1.27 ± 0.88 | 0.854 | TG | 1.64 ± 0.53 | 1.4 ± 0.44 | 1.46 ± 0.68 | 0.621 | 1.68 ± 0.88 | 1.92 ± 1.22 | 1.86 ± 0.93 | 0.679 |
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Note: SD = standard deviation; BMI = body mass index; WHR = waist-to-hip ratio; FPG = fasting plasma glucose; HbA1c = hemoglobin A1c; SBP = systolic blood pressure; DBP = Diastolic blood pressure; Chol = cholesterol; LDL = low-density lipid; HDL = high-density lipid; TG = triglyceride. aOne-way ANOVA.
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