Research Article
Association of Endothelin-Converting Enzyme and Endothelin-1 Gene Polymorphisms with Essential Hypertension in Malay Ethnics
Table 6
Genotypic distribution in female and male.
| Gene | Gender | Genotype | Control n (%) | Case n (%) | value | OR | 95% CI LL | 95% CI UL |
| ET-1 | Male | GG | 77 (78.6) | 9 (8.5) | <0.001 | Ref | | | GT | 14 (14.3) | 31 (29.2) | <0.001 | 23.178 | 5.618 | 95.629 | TT | 7 (7.1) | 66 (62.3) | <0.001 | 71.696 | 14.69 | 349.912 | Female | GG | 71 (72.4) | 7 (9.9) | <0.001 | Ref | | | GT | 17 (17.3) | 15 (21.1) | 0.185 | 2.764 | 0.614 | 12.433 | TT | 10 (10.2) | 49 (69) | <0.001 | 13.683 | 3.339 | 56.061 |
| ECE | Male | CC | 5 (5.1) | 8 (7.5) | 0.736 | 0.83 | 0.078 | 8.847 | CT | 9 (9.2) | 24 (22.6) | 0.837 | 1.306 | 0.103 | 16.574 | TT | 84 (85.7) | 74 (69.8) | 0.877 | Ref | | | Female | CC | 7 (7.1) | 11 (15.5) | 0.34 | 0.348 | 0.05 | 2.404 | CT | 7 (7.1) | 17 (23.9) | 0.799 | 0.751 | 0.083 | 6.809 | TT | 84 (85.7) | 43 (60.6) | 0.284 | Ref | | |
|
|
Notes: CI = confidence interval; the analysis was adjusted based on age and BMI as covariates.
|