Research Article
TLR-8, TNF-α, and ESR-1α Gene Polymorphism Susceptibility in Onset of Arthritis
Table 2
Single site analysis of all targeted polymorphic sites in RA as well as OA subjects.
| | Gene | Allele/genotype | RA frequency (P/C) | X2 value | value | OA frequency (P/C) | X2 value | value |
| | TLR-8 | Rs3764879 | | | | | | | | C | 0.057/1.000 | 1290.075 | 0.002 | 0.361/1.000 | 729.016 | >0.01 | | G | 0.943/0.000 | 0.639/0.000 | | GG | 0.887/0.000 | 711.999 | >0.01 | 0.278/0.000 | 727.999 | 0.002 | | CG | 0.113/0.000 | 0.722/0.000 | | CC | 0.000/1.000 | 0.000/1.000 | | Rs3764880 | | | | | | | | A | 0.088/1.000 | 1219.788 | >0.01 | 0.196/1.000 | 1017.99 | >0.01 | | G | 0.912/0.000 | 0.804/0.000 | | GG | 0.823/0.000 | 712.000 | 0.001 | 0.608/0.000 | 728.000 | 0.001 | | AG | 0.177/0.000 | 0.392/0.000 | | AA | 0.000/1.000 | 0.000/1.000 | | Rs5744080 | | | | | | | | C | 0.170/0.981 | 988.959 | >0.01 | 0.038/0.981 | 1297.66 | >0.001 | | G | 0.830/0.019 | 0.962/0.019 | | TT | 0.660/0.000 | 655.964 | 0.002 | 0.924/0.000 | 688.920 | >0.01 | | CT | 0.340/0.039 | 0.076/0.039 | | CC | 0.000/0.961 | 0.000/0.961 | | SCV000844945 | | | | | | | | C | 0.500/0.000 | 521.964 | >0.01 | 0.524/0.000 | 558.531 | 0.001 | | T | 0.500/1.000 | 0.476/1.000 | | CC | 0.000/0.000 | 712.000 | 0.001 | 0.047/0.000 | 728.000 | 0.001 | | CG | 1.000/0.000 | 0.953/0.000 | | GG | 0.000/1.000 | 0.000/1.000 | | SCV000844946 | | | | | | | | A | 0.500/0.000 | 521.964 | 0.000 | 0.741/0.000 | 899.208 | >0.01 | | T | 0.500/1.000 | 0.259/1.000 | | | | AA | 0.000/0.000 | 712.000 | 0.001 | 0.481/0.000 | 727.999 | 0.002 | | AT | 1.000/0.000 | 0.519/0.000 | | TT | 0.000/1.000 | 0.000/1.000 |
| | TNF | Rs1800629 | | | | | | | | G | 0.722/0.000 | 753.867 | >0.01 | 0.910/0.000 | 1023.640 | >0.01 | | A | 0.228/1.000 | 0.090/1.000 | | GG | 0.543/0.000 | 600.000 | 0.001 | 0.820/0.000 | 616.000 | 0.002 | | AG | 0.457/0.000 | 0.180/0.000 | | AA | 0.000/1.000 | 0.000/1.000 | | Rs361525 | | | | | | | | G | 1.000/1.000 | — | — | 1.000/1.000 | — | — | | GG | 1.000/1.000 | — | — | 1.000/1.000 | — | — |
| | ESR-1α | Rs2234693 | | | | | | | | C | 1.000/1.000 | — | — | 1.000/1.000 | — | — | | CC | 1.000/1.000 | — | — | 1.000/1.000 | — | — | | Rs93407779 | | | | | | | | C | 1.000/1.000 | — | — | 1.000/1.000 | — | — | | CC | 1.000/1.000 | — | — | 1.000/1.000 | — | — | | Rs2228480 | | | | | | | | A | 0.127/1.000 | 930.177 | 0.002 | 0.286/1.000 | 675.414 | 0.002 | | G | 0.873/0.000 | 0.714/0.000 | | AA | 0.000/1.000 | 600.000 | 0.002 | 0.073/1.000 | 530.493 | 0.002 | | AG | 0.253/0.000 | 0.427/0.000 | | GG | 0.747/0.000 | 0.500/0.000 | | Rs1451500 | | | | | | | | A | 0.342/1.000 | 588.819 | >0.01 | 0.509/1.000 | 393.256 | 0.001 | | G | 0.658/0.000 | 0.491/0.000 | | AA | 0.057/1.000 | 535.645 | >0.01 | 0.041/1.000 | 566.126 | 0.001 | | AG | 0.570/0.000 | 0.937/0.000 | | GG | 0.373/0.000 | 0.022/0.000 | | SCV000804801 | | | | | | | | A | 0.455/0.000 | 353.398 | 0.001 | 0.562/0.000 | 473.449 | 0.001 | | G | 0.545/1.000 | 0.438/1.000 | | AA | — | 500.917 | 0.001 | 0.123/0.000 | 616.000 | 0.002 | | AG | 0.910/0.000 | 0.877/0.000 | | GG | 0.090/1.000 | 0.000/1.000 | | SCV000804802 | | | | | | | | A | 0.437/0.000 | 335.181 | 0.002 | 0.628/0.000 | 564.014 | 0.001 | | T | 0.563/1.000 | 0.372/1.000 | | AA | 0.130/0.000 | 354.907 | 0.001 | 0.256/0.000 | 616.000 | 0.002 | | AT | 0.613/0.000 | 0.744/0.000 | | TT | 0.257/1.000 | 0.000/1.000 |
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