Research Article
TLR-8, TNF-α, and ESR-1α Gene Polymorphism Susceptibility in Onset of Arthritis
Table 3
Haplotype analysis of TLR-8 and ESR-1α gene.
| | Haplotype | RA frequency (P/C) | value | Haplotype | OA frequency (P/C) | value |
| | Haplotype: rs3764879, rs3764880, rs5744080, SCV000844945, SCV000844946 | | TLR-8 | | CACGT | 0.000/0.981 | 0.006 | CACGT | 0.000/0.981 | 0.001 | | CATGT | 0.000/0.019 | 0.0005 | CATGT | 0.000/0.019 | 0.0004 | | CGCCA | 0.014/0.000 | 0.005 | CATCA | 0.075/0.000 | 0.001 | | CGCCT | 0.014/0.000 | 0.005 | CATCT | 0.040/0.000 | 0.009 | | CGCGA | 0.014/0.000 | 0.005 | CGTCA | 0.176/0.000 | 0.001 | | CGCGT | 0.014/0.000 | 0.0005 | CGTCT | 0.070/0.000 | 0.001 | | GATCA | 0.013/0.000 | 0.001 | GATCA | 0.013/0.000 | 0.009 | | GATCT | 0.018/0.000 | 0.001 | GATCT | 0.068/0.000 | 0.001 | | GATGA | 0.018/0.000 | 0.001 | GGCCT | 0.038/0.000 | 0.008 | | GTTGT | 0.018/0.000 | 0.001 | GGTCT | 0.043/0.000 | 0.009 | | GGCCA | 0.018/0.000 | 0.0006 | GGTGC | 0.476/0.000 | 0.002 | | GGCCT | 0.024/0.000 | 0.0006 | | | | | GGCGA | 0.024/0.000 | 0.006 | | | | | GGCGT | 0.024/0.000 | 0.0006 | | | |
| | Haplotype: rs2228480, rs1451501590, SCV000804801, SCV000804802 | | ESR-1α | | AAGT | 0.025/1.000 | 0.002 | AAGT | 0.000/1.000 | 0.002 | | AAAT | 0.003/0.000 | — | AAAA | 0.218/0.000 | 0.002 | | AGGT | 0.098/0.000 | 0.001 | AGAA | 0.005/0.000 | — | | GAGA | 0.311/0.000 | 0.001 | AGGA | 0.064/0.000 | 0.001 | | GAGT | 0.002/0.000 | — | AGGT | 0.000/0.000 | — | | GGAA | 0.067/0.000 | 0.001 | GAAA | 0.292/0.000 | 0.001 | | GGAT | 0.385/0.000 | 0.001 | GGAA | 0.047/0.000 | 0.008 | | GGGA | 0.059/0.000 | 0.009 | GGGA | 0.003/0.000 | — | | GGGT | 0.050/0.000 | 0.008 | GGGT | 0.372/0.000 | 0.002 |
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