Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction

Figure 3

The role of SIRT2 in various metabolic disorders. SIRT2 promotes the progression of Huntington’s disease, acute ischaemic stroke, multiple myeloma, prostate cancer, clear-cell renal cell carcinoma, liver cancer, gastric cancer, and ischaemia reperfusion injury. SIRT2 inhibits the progression of traumatic brain injury coronary heart disease, nonalcoholic fatty liver disease, heart failure, cardiac hypertrophy, myocardial hypertrophy, and myocardial infarction. The role of SIRT2 in type 2 diabetes, colorectal cancer, and breast cancer remains controversial.