Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction

Table 1

Posttranslational modifications involving SIRT2.

Types of post-translational modifications	Types of catalytic proteins	SIRT2 catalytic effect	Function
Acetylation (Kac)	Histone; non histone	Deacetylation	Regulates transcription and diverse biological processes [17–20]
Methacrylation (Kmea)	Histone	Removes H3K18mea	Enables crosstalk between metabolism and epigenetic regulation, and the specific mechanism needs further study [21]
Crotonylation ((Kcr))	Histone	Removes Kcr	Regulates transcription [22, 23]
Benzoylation (Kbz)	Histone	Removes histone Kbz	Regulates transcription [24, 25]
Gamma-oxononanoylation (Kgon)	Histone	Removes histone Kgon	Interferes with histone assembly into nucleosomes [26, 27]
4-Oxononanoylation (4-ONylation)	Histone	Removes 4-ONyl	Prevents nucleosome assembly under oxidative stress [28]
Lipoylation	Nonhistone	Delipoylation	Regulates cell metabolism [29]
Myristoylation	Nonhistone	Demyristoylates ADP-ribosylation factor 6 (ARF6) K3	Promotes ARF6 activation [30]