Associations between Extracellular Matrix Protein 1 Gene Polymorphism and Progression of Liver Disease
Table 4
Genotype and allele frequencies of SNPs in the ECM1 gene in each group.
SNP
Healthy control
Chronic HBV infection patient
Chronic HBV infection patient (N = 656) vs. healthy control (N = 298)
Non-HCC (N = 370)
HBV-related HCC (N = 286)
N (%)
N (%)
OR (95% CI)
-valuea
N (%)
OR (95% CI)
-valueb
OR (95% CI)
-valuec
Rs3834087 genotype and allele
Detected number
N = 298
N = 370
N = 286
N = 656 vs. N = 286
GAG/GAG
245 (82.2)
330 (89.2)
1
243 (85.0)
1
1
GAG/-
53 (17.8)
39 (10.5)
0.54 (0.35-0.85)
0.0068
43 (15.0)
0.79 (0.50-1.23)
0.2921
0.65 (0.45-0.95)
0.0248
-/-
0 (0.0)
1 (0.3)
—
1.0000
0 (0.0)
—
—
—
1.0000
GAG/- + -/-
53
40
0.55 (0.35-0.86)
0.0089
43
0.79 (0.50-1.23)
0.2923
0.66 (0.45-0.96)
0.0287
GAG allele
543 (91.1)
699 (94.5)
1
529 (92.5)
1
1
DEL allele
53 (8.9)
41 (5.5)
0.60 (0.39-0.92)
0.0172
43 (7.5)
0.83 (0.55-1.27)
0.3922
0.70 (0.49-1.00)
0.0514
Rs3754217 genotype and allele
Detected number
N = 294
N = 369
N = 284
N = 653 vs. N = 294
GG
144 (49.0)
210 (56.9)
1
146 (51.4)
1
1
GT
132 (44.9)
134 (36.3)
0.68 (0.49-0.94)
0.0209
114 (40.1)
0.83 (0.59-1.17)
0.2782
0.75 (0.56-1.00)
0.0481
TT
18 (6.1)
25 (6.8)
0.95 (0.50-1.82)
0.8850
24 (8.5)
1.31 (0.68-2.55)
0.4180
1.11 (0.63-1.98)
0.7152
GT + TT
150
43
0.71 (0.52-0.98)
0.0351
138
0.88 (0.63-1.23)
0.4642
0.79 (0.60-1.04)
0.0981
G allele
420 (71.4)
554 (75.1)
1
406 (71.5)
1
1
T allele
168 (28.6)
184 (24.9)
0.83 (0.65-1.06)
0.1358
162 (28.5)
1.00 (0.77-1.29)
0.9847
0.90 (0.73-1.12)
0.3469
Rs3737240 genotype and allele
Detected number
N = 296
N = 369
N = 286
N = 655 vs. N = 296
CC
176 (59.5)
224 (60.7)
1
169 (59.3)
1
1
CT
102 (34.5)
127 (34.4)
0.96 (0.69-1.34)
0.8270
100 (35.1)
1.02 (0.71-1.44)
0.9335
0.99 (0.74-1.33)
0.9441
TT
18 (6.1)
18 (4.9)
0.79 (0.40-1.57)
0.4982
16 (5.6)
0.91 (0.47-1.86)
0.7979
0.85 (0.47-1.56)
0.6069
CT + TT
120
145
0.94 (0.68-1.29)
0.6870
116
1.00 (0.71-1.40)
0.8231
0.97 (0.73-1.28)
0.8282
C allele
454 (76.7)
575 (77.9)
1
438 (76.8)
1
1
T allele
138 (23.3)
163 (22.1)
0.94 (0.64-1.37)
0.7415
132 (23.2)
1.00 (0.76-1.31)
0.9783
0.98 (0.76-1.26)
0.8509
Rs13294 genotype and allele
Detected number
N = 297
N = 369
N = 285
N = 654 vs. N = 297
GG
176 (59.3)
224 (60.7)
1
169 (59.3)
1
1
GA
104 (35.0)
127 (34.4)
0.94 (0.68-1.31)
0.7223
100 (35.1)
1.00 (0.70-1.24)
0.9969
0.97 (0.72-1.30)
0.8412
AA
17 (5.7)
18 (4.9)
0.84 (0.42-1.68)
0.6120
16 (5.6)
0.96 (0.47-1.98)
0.9091
0.90 (0.49-1.66)
0.7423
GA + AA
121
145
0.93 (0.68-1.27)
0.6412
116
0.99 (0.71-1.39)
0.9701
0.96 (0.73-1.27)
0.7811
G allele
456 (76.8)
575 (77.9)
1
438 (76.8)
1
1
A allele
138 (23.2)
163 (22.1)
0.94 (0.72-1.21)
0.6192
132 (23.2)
1.00 (0.76-1.31)
0.9763
0.96 (0.76-1.21)
0.7444
-value a,b,c represents the non-HCC, HCC, and chronic HBV infection patients compared to the healthy control groups adjusted for age, gender, smoking, and drinking by logistic regression analysis. The two-sided χ2 test or Fisher’s exact test was used in allele distribution comparison. CI, confidence interval; ECM, extracellular matrix; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; OR, odds ratio; SNP, single nucleotide polymorphism.
