Associations between Extracellular Matrix Protein 1 Gene Polymorphism and Progression of Liver Disease
Table 5
Genotype and allele frequencies of SNPs in the ECM1 gene in chronic HBV infection subgroups.
CHB
LC
CHB vs. LC
HCC
LC vs. HCC
Non-HCC
Non-HCC vs. HCC
N (%)
N (%)
OR (95% CI)a
-valuea
N (%)
OR (95% CI)b
-valueb
N (%)
OR (95% CI)c
-valuec
Rs3834087 genotype and allele
Detected number
N = 104
N = 266(%)
N = 286(%)
N = 370(%)
GAG/GAG
96 (92.3)
234 (88.0)
1
243 (85.0)
1
330 (89.2)
1
GAG/-
8 (7.7)
31 (11.7)
1.63 (0.72-3.68)
0.2442
43 (15.0)
1.24 (0.75-2.05)
0.4121
39 (10.5)
1.40 (0.87-2.25)
0.1622
-/-
0 (0.0)
1 (0.4)
1.00 (0.99-1.01)
1.0000
0 (0.0)
1.00 (0.99-1.00)
0.4922
1 (0.3)
1.00 (0.99-1.00)
1.0000
GAG/- + -/-
8
32
1.67 (0.74-3.78)
0.2162
43
1.19 (0.72-1.97)
0.4884
40
1.36 (0.85-2.18)
0.1963
GAG allele
200 (96.2)
499 (93.8)
1
529 (92.5)
1
699 (94.5)
1
Del allele
8 (3.8)
33 (6.2)
1.65 (0.75-3.64)
0.2082
43 (7.5)
1.23 (0.77-1.97)
0.3894
41 (5.5)
1.39 (0.89-2.16)
0.1472
Rs3754217 genotype and allele
Detected number
N = 104
N = 265
N = 284
N = 369
GG
61 (58.7)
149 (56.2)
1
146 (54.1)
1
210 (56.9)
1
GT
37 (35.6)
97 (36.6)
1.15 (0.70-1.88)
0.5791
114 (40.1)
1.18 (0.82-169)
0.3693
134 (36.3)
1.20 (0.86-1.68)
0.2749
TT
6 (5.8)
19 (7.2)
1.35 (0.51-3.56)
0.5512
24 (8.5)
1.13 (0.59-2.19)
0.7068
25 (6.8)
1.24 (0.67-2.29)
0.4901
GT + TT
43
116
1.18 (0.74-1.88)
0.4592
138
1.17 (0.83-1.65)
0.3642
159
1.21 (0.88-1.66)
0.2381
G allele
159 (76.4)
395 (74.5)
1
406 (71.5)
1
554 (75.1)
1
T allele
49 (23.6)
135 (25.5)
1.11 (0.76-1.61)
0.5891
162 (28.5)
1.17 (0.89-1.53)
0.2559
184 (24.9)
1.20 (0.94-1.54)
0.1449
Rs3737240 genotype and allele
Detected number
N = 104
N = 265
N = 285
N = 369
CC
62 (59.6)
162 (61.1)
1
169 (59.3)
1
224 (60.7)
1
CT
38 (36.5)
89 (33.6)
0.95 (0.58-1.55)
0.8401
100 (35.1)
0.961 (0.74-1.53)
0.7572
127 (34.4)
1.03 (0.73-1.44)
0.8821
TT
4 (3.8)
14 (5.3)
1.35 (0.42-4.27)
0.6151
16 (5.6)
1.04 (0.49-2.24)
0.9132
18 (4.9)
1.12 (0.55-2.29)
0.7623
CT + TT
42
103
0.90 (0.62-1.59)
0.9679
116
1.06 (0.75-1.50)
0.7546
145
1.04 (0.75-1.43)
0.8229
C allele
162 (77.9)
413 (77.9)
1
438 (76.8)
1
575 (77.9)
1
T allele
46 (22.1)
117 (22.1)
0.99 (0.68-1.47)
0.9914
132 (23.2)
0.93 (0.70-1.23)
0.6223
163 (22.1)
1.06 (0.73-1.55)
0.7585
Rs13294 genotype and allele
Detected number
N = 104
N = 265
N = 285
N = 369
GG
62 (59.6)
162 (61.1)
1
169 (59.3)
1
224 (60.7)
1
GA
38 (36.5)
89 (33.6)
0.95 (0.58-1.55)
0.8401
100 (35.1)
1.06 (0.74-1.53)
0.7572
127 (34.4)
1.03 (0.73-1.44)
0.8822
AA
4 (3.8)
14 (5.3)
1.35 (0.42-4.27)
0.6145
16 (5.6)
1.04 (0.49-2.24)
0.9127
18 (4.9)
1.12 (0.55-2.29)
0.7615
GA + AA
42
103
0.99 (0.62-1.59)
0.9682
116
1.06 (0.75-1.50)
0.7550
145
1.04 (0.75-1.43)
0.8230
G allele
162 (77.9)
413 (77.9)
1
438 (76.8)
1
575 (77.9)
1
A allele
46 (22.1)
117 (22.1)
1.00 (0.68-1.47)
0.9911
132 (23.2)
1.06 (0.80-1.41)
0.6682
163 (22.1)
1.06 (0.82-1.38)
0.6462
-valuea,b,c represents the comparison adjusted for age, gender, smoking, and drinking by logistic regression analysis. The two-sided χ2 test or Fisher’s exact test was used in allele distribution comparison. CHB, chronic hepatitis B; CI, confidence interval; ECM, extracellular matrix; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; LC, liver cirrhosis; OR, odds ratio; SNP, single nucleotide polymorphism.
