Genetic Variations in the Human Angiotensin-ConvertingEnzyme 2 and Susceptibility to Coronavirus Disease-19

Figure 1

(a) The image illustrates the intracellular interactions between angiotensin-converting enzyme 2 and its ligand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (b) The image shows ACE2 expression in 15 primates and 16 tissues. The level for significantly expressed genes is color-coded in 8 equally sized bins (light-to-dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above the intergenic background), while dark gray is for no expression or no sequence conservation (0 read in the gene). The plot on the right shows the distribution of the measured expression values in all tissues for all genes (blue) and for this gene in magic index = log2 (1000 sFPKM). HUM: human, CHP: chimpanzee, PTM: pig-tailed Macaque, JMI: Japanese macaque, RMI: rhesus macaque Indian, RMC: rhesus macaque Chinese, CMM: cynomolgus macaque Mauritian, CMC: cynomolgus macaque Chinese, BAB: olive baboon, SMY: sooty mangabey, MST: common marmoset, SQM: squirrel monkey, OWL: owl monkey, MLM: mouse Lemur, RTL: ring-tailed lemur. This information was obtained from the AceView database (https://www.ncbi.nlm.nih.gov/ieb/research/acembly/).

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