The Clinical and Cellular Impact of RBMS2 on the Progression and Prognosis of Kidney Renal Clear Cell Carcinoma

Table 2

ccRCC overall survival analysis.

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Gender	541		0.614
Female	187	Reference
Male	354	0.924 (0.679–1.257)	0.613
Age	541		<0.001
≤60	269	Reference		Reference
>60	272	1.791 (1.319–2.432)	<0.001	1.728 (1.046–2.854)	0.033
Serum calcium	367		0.076
Low	204	Reference		Reference
Normal and elevated	163	1.356 (0.969–1.899)	0.076	0.622 (0.380–1.018)	0.059
Histologic grade	533		<0.001
G1 and G2	250	Reference		Reference
G3 and G4	283	2.665 (1.898–3.743)	<0.001	0.985 (0.560–1.735)	0.960
Pathologic T stage	541		<0.001
T1 and T2	350	Reference		Reference
T3 and T4	191	3.210 (2.373–4.342)	<0.001	2.207 (1.304–3.737)	0.003
Pathologic N stage	258		0.001
N0	242	Reference		Reference
N1	16	3.422 (1.817–6.446)	<0.001	0.829 (0.308–2.232)	0.710
Pathologic M stage	508		<0.001
M0	429	Reference		Reference
M1	79	4.401 (3.226–6.002)	<0.001	5.154 (2.926–9.080)	<0.001
RBMS2	541		<0.001
Low	270	Reference		Reference
High	271	0.545 (0.399–0.744)	<0.001	0.719 (0.436–1.184)	0.195

Bold values indicate P<0.05.