The Clinical and Cellular Impact of RBMS2 on the Progression and Prognosis of Kidney Renal Clear Cell Carcinoma

Table 3

ccRCC disease-free survival analysis.

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Gender	530		0.415
Female	181	Reference
Male	349	1.183 (0.786–1.781)	0.420
Age	530		0.117
≤60	265	Reference
>60	265	1.351 (0.926–1.971)	0.118
Serum calcium	361		0.056
Low	200	Reference		Reference
Normal and elevated	161	1.507 (0.989–2.298)	0.057	0.570 (0.312–1.041)	0.067
Histologic grade	522		<0.001
G1 and G2	249	Reference		Reference
G3 and G4	273	4.850 (2.925–8.043)	<0.001	0.936 (0.429–2.039)	0.867
Pathologic T stage	530		<0.001
T1 and T2	347	Reference		Reference
T3 and T4	183	5.606 (3.697–8.502)	<0.001	3.590 (1.752–7.358)	<0.001
Pathologic N stage	256		0.003
N0	241	Reference		Reference
N1	15	3.864 (1.831–8.157)	<0.001	0.764 (0.274–2.124)	0.605
Pathologic M stage	497		<0.001
M0	422	Reference		Reference
M1	75	9.219 (6.294–13.504)	<0.001	9.294 (4.797–18.004)	<0.001
RBMS2	530		<0.001
Low	265	Reference		Reference
High	265	0.352 (0.229–0.540)	<0.001	0.387 (0.203–0.737)	0.004

Bold values indicate P<0.05.