The Clinical and Cellular Impact of RBMS2 on the Progression and Prognosis of Kidney Renal Clear Cell Carcinoma

Table 4

ccRCC progression-free survival.

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Gender	539		0.024
Female	186	Reference		Reference
Male	353	1.476 (1.043–2.090)	0.028	1.650 (0.980–2.779)	0.060
Age	539		0.113
≤60	268	Reference
>60	271	1.285 (0.942–1.754)	0.114
Serum calcium	366		0.054
Low	203	Reference		Reference
Normal and elevated	163	1.422 (0.994–2.034)	0.054	0.520 (0.301–0.901)	0.020
Histologic grade	531		<0.001
G1 and G2	250	Reference		Reference
G3 and G4	281	3.684 (2.530–5.364)	<0.001	0.873 (0.465–1.639)	0.672
Pathologic T stage	539		<0.001
T1 and T2	350	Reference		Reference
T3 and T4	189	4.569 (3.306–6.314)	<0.001	3.443 (1.923–6.167)	< 0.001
Pathologic N stage	257		0.001
N0	241	Reference		Reference
N1	16	3.697 (1.899–7.198)	<0.001	0.461 (0.166–1.276)	0.136
Pathologic M stage	506		<0.001
M0	429	Reference		Reference
M1	77	9.081 (6.554–12.582)	<0.001	15.996 (7.983–32.049)	< 0.001
RBMS2	539		<0.001
Low	268	Reference		Reference
High	271	0.481 (0.347–0.668)	<0.001	0.527 (0.308–0.903)	0.020

Bold values indicate P<0.05.