Orthodenticle Homeobox OTX1 Promotes Papillary Thyroid Carcinoma Progression and Is a Potential Prognostic Biomarker

Table 2

Correlations between OTX1 expression and PTC patients’ characteristics.

Variables	Cases (n = 294)	OTX1 level		value
		Low (n = 156)	High (n = 138)
Age (years)
<49	147	74	73	0.350
≥49	147	82	65
Sex
Female	220	116	104	0.843
Male	74	40	34
Laterality
Left lobe	127	69	58	0.746
Right lobe	143	76	67
Bilateral	24	11	13
Tumor diameter (cm)
<1.7	147	89	58	0.010
≥1.7	147	67	80
Differentiation grade
Well differentiated	232	129	103	0.173
Moderately differentiated	38	15	23
Poorly differentiated	24	12	12
T stage
T1	149	90	59	0.051
T2	55	24	31
T3	73	36	37
T4	17	6	11
N stage
N0	238	136	102	0.007
N1a	33	14	19
N1b	23	6	17
Surgery
Lobectomy and/or isthmectomy	49	27	22	0.850
Subtotal or near total thyroidectomy	10	6	4
Total thyroidectomy	235	123	112
Radiotherapy
Absent	169	94	75	0.306
Accepted	125	62	63

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