Orthodenticle Homeobox OTX1 Promotes Papillary Thyroid Carcinoma Progression and Is a Potential Prognostic Biomarker

Table 3

Kaplan–Meier survival analyses of the enrolled PTC cohort.

Variables	Cases (n = 294)	Survival months (mean ± S.D.)	5-year CSS (%)	value
Age (years)
<49	147	81.5 ± 0.5	99.3	0.022
≥49	147	78.9 ± 1.4	93.2
Sex
Female	220	81.3 ± 0.8	97.6	0.190
Male	74	78.9 ± 2.0	92.2
Laterality
Left lobe	127	81.2 ± 1.0	97.4	0.828
Right lobe	143	80.4 ± 1.2	95.1
Bilateral	24	73.9 ± 3.1	95.8
Tumor diameter (cm)
<1.7	147	—	100	0.002
≥1.7	147	—	92.3
Differentiation grade
Well differentiated	232	—	99.5	<0.001
Moderately differentiated	38	—	100
Poorly differentiated	24	—	59.1
T stage
T1	149	—	100	<0.001
T2	55	—	100
T3	73	—	96.1
T4	17	—	51.8
N stage
N0	238	81.7 ± 0.6	97.3	<0.001
N1a	33	79.8 ± 2.1	97.0
N1b	23	67.2 ± 5.8	82.4
Surgery
Lobectomy and/or isthmectomy	49	—	97.9	0.708
Subtotal or near total thyroidectomy	10	—	100
Total thyroidectomy	235	—	95.5
Radiotherapy
Absent	169	81.1 ± 0.9	96.4	0.469
Accepted	125	80.3 ± 1.3	95.6
OTX1 expression level
Low	156	82.1 ± 0.6	97.9	0.044
High	138	76.2 ± 1.4	94.3

.