XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population

Table 1

Analysis of the XRCC1 C194T and G399A polymorphisms in CRC patients and controls from northeastern México.

Genotype/alleles C194T	Controls, n = 146	Patients, n = 146	OR (95% CI)	^a
CC	103	107	1.0 (reference)
CT	40	39	0.94 (0.56–1.57)	0.81^b
TT	3	0	0.14 (0.007–2.70)	0.19^b
CT + TT	43	39	0.87 (0.52–1.46)	0.60^c
C	246	253	1.0 (reference)
T	46	39	0.82 (0.52–1.31)	0.41
G399A	n = 155	n = 155		^a
GG	92	77	1.0 (reference)
GA	58	65	1.34 (0.84–2.13)	0.22^b
AA	5	13	3.11 (1.06–9.10)	0.031^b
GA + AA	63	78	1.48 (0.94–2.32)	0.087^c
G	242	219	1.0 (reference)
A	68	91	1.48 (1.03–2.13)	0.034

n: sample size; OR: odds ratio; CI: confidence interval; : value. ^aPearson’s chi-square test. ^bCodominant model. ^cDominant model. Bold indicates that the A allele and the AA genotype were associated with colorectal cancer.