XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population

Table 2

Analysis of the XRCC1 G399A polymorphism in populations worldwide.

^aCountry	Controls/cases	OR (95% CI)	^b value	Reference
Korea	209/209	1.39 (1.00–1.93)	0.047	[9]
Poland	153/113	1.51 (1.07–2.15)	0.02	[10]
Poland	310/318	1.35 (1.08–1.70)	0.01	[11]
China	970/485	1.42 (1.20–1.69)	0.001	[12]
China	350/320	1.41 (1.10–1.79)	0.006	[13]
Japan	776/685	1.19 (1.01–1.41)	0.04	[14]
Romania	162/150	2.37 (1.69–3.32)	0.0001	[15]
Thailand	230/230	1.60 (1.20–2.13)	0.001	[16]
Iran	150/150	1.54 (1.10–2.10)	0.01	[17]
Iran	160/180	1.50 (1.07–2.10)	0.018	[18]
Taiwan	729/718	0.89 (0.76–1.06)	0.19	[19]
Norway	399/157	0.92 (0.71–1.21)	0.56	[20]
Spain	322/355	0.96 (0.77–1.21)	0.74	[21]
Poland	100/100	0.84 (0.56–1.26)	0.41	[22]
Poland	100/133	1.08 (0.74–1.58)	0.69	[23]
Singapore	1120/294	0.87 (0.71–1.08)	0.21	[24]
Italy	121/109	1.10 (0.74–1.63)	0.64	[25]
Czech Republic	530/532	0.94 (0.79–1.12)	0.48	[26]
USA	1950/1582	0.95 (0.86–1.05)	0.33	[27]
USA	360/305	1.00 (0.80–1.25)	1.00	[28]
México	120/103	1.21 (0.80–1.83)	0.36	[29]
India	146/120	0.77 (0.55–1.10)	0.15	[30]
India	150/130	0.89 (0.63–1.26)	0.51	[31]
China	630/451	0.99 (0.82–1.19)	0.92	[32]
Sweden	558/452	1.12 (0.94–1.35)	0.21	[33]
Malaysia	212/130	1.04 (0.74–1.46)	0.81	[34]

^aOnly case-control studies with at least 100 patients and 100 controls reporting genotype frequencies were included. Meta-analyses were excluded. ^bComparisons were made using Pearson’s chi-square test with the G allele as the reference. Bold indicates a significance for the A allele with colorectal cancer.