XRCC1 R194W and R399Q Polymorphisms and Colorectal Cancer Risk in a Northeastern Mexican Population

Table 3

Analysis of the XRCC1 C194T polymorphism in several countries.

^aCountry	Controls/cases	OR (95% CI)	^b value	Reference
China	438/438	1.30 (1.04–1.64)	0.023	[8]
Korea	168/209	2.87 (2.01–4.11)	0.0001	[9]
China	628/451	1.29 (1.07–1.55)	0.007	[32]
Iran	140/291	4.95 (2.11–11.6)	0.001	[35]
China	350/320	0.86 (0.68–1.08)	0.19	[13]
Japan	776/685	0.99 (0.85–1.16)	1.0	[14]
Norway	399/156	1.24 (0.74–2.08)	0.41	[20]
Spain	322/360	0.89 (0.58–1.35)	0.58	[21]
Poland	100/100	1.11 (0.46–2.67)	0.82	[22]
Poland	100/133	1.76 (0.71–4.37)	0.21	[23]
Singapore	1162/305	0.93 (0.76–1.24)	0.48	[24]
Italy	121/109	1.26 (0.64–2.50)	0.50	[25]
USA	1950/1582	1.19 (0.97–1.45)	0.09	[27]
USA	360/305	0.86 (0.58–1.29)	0.46	[28]
México	120/107	0.60 (0.34–1.06)	0.07	[29]
Malaysia	212/130	0.96 (0.68–1.35)	0.82	[34]

^aOnly case-control studies with at least 100 patients and 100 controls reporting genotype frequencies were included. Meta-analyses were excluded. ^bComparisons were made using Pearson’s chi-square test with the C allele as the reference. Bold values indicate a significance for the T allele with colorectal cancer.