Identification of Key Biomarkers and Candidate Molecules in Non-Small-Cell Lung Cancer by Integrated Bioinformatics Analysis

Figure 10

The biological role of SPP1 in tumors. (a) Immunohistochemical analysis of normal lung tissues and lung adenocarcinoma with the HPA online tool, and SPP1 was found to be highly expressed in LUAD tissues. (b) Expression of SPP1 in various tumors. (c) The methylation level of SPP1 in normal lung tissues and lung adenocarcinoma. (d) Expression of SPP1 in lung adenocarcinoma based on nodal metastasis status. (e) Interacting proteins for SPP1 gene STRING interaction network preview (showing top 10 STRING interactants). (f) Beautify the results of KEGG pathway analysis with the CLUGO plugin in Cytoscape software. (g) Variation of SPP1 related genes in the lungs. (h) Analysis of the network of regulatory pathways of the 11 genes. The white is for tumor-targeted drugs, and yellow is for oncology drugs approved by the FDA. (i) The scatter plot showed the correlation between the SPP1 expression and the 7 hub gene signature. , , and .

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