Identification of Key Biomarkers and Candidate Molecules in Non-Small-Cell Lung Cancer by Integrated Bioinformatics Analysis

Figure 9

The biological role of PIK3R1 in tumors. (a) Immunohistochemical analysis of normal lung tissues and lung adenocarcinoma with the HPA online tool, and PIK3R1 was found to be expressed lower in LUAD tissues. (b) Expression of PIK3R1 in various tumors. (c) Interacting proteins for PIK3R1 gene STRING interaction network preview (showing top 10 STRING interactants). (d) Bubble diagram of the PANTHER pathway of PIK3R1 gene. Significant pathways with P value <0.05 and top 24 were plotted by R language. (e) Variation of PIK3R1 related genes in lung adenocarcinoma. (f) Analysis of the network of regulatory pathways of the 11 genes. White is for tumortargeted drugs, and yellow is for oncology drugs approved by the FDA. (g) The scatter plot showed the correlation between PIK3R1 expression and 7 hub gene signature.

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