Bioinformatics-Based Identification of CircRNA-MicroRNA-mRNA Network for Calcific Aortic Valve Disease

Figure 9

Schematic representation of the role of three circRNA-miRNA-mRNA regulatory networks in promoting CAVD. Has_circ_0026817-hsa-miR-211-5p-CACNA1C encodes enhanced L-type calcium channels that promote calcium influx into VICs, leading to calcification. In addition, hsa_circ_0026817 targets hsa-miR-211-5p through sponge activity, regulates cyclin D1, and promotes proliferation of VICs. Hsa_circ_0007215-hsa-miR-1252-5p-MECP2 regulates calcium channels through the MAPK pathway and is involved in calcification of VICs. Hsa_circ_0007215-hsa-miR-1343-3p-RBL1 is regulated by TGF-β signaling. RBL1 is inhibited in VEC, blocking G1-S phase cell cycle progression and regulating VECs proliferation. In hsa_circ_0007215-hsa-miR-1343-3p-RBL1, TGF-β signaling is able to regulate RBL1 to block cell cycle progression in G1-S phase and regulate proliferation of VECs.