Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Blood LC-MS/MS Protein Profiling in Healthy Subjects

Figure 2

(a) Correspondence analysis (CA) plot of healthy subjects’ nondepleted serum using the expression dataset of 15 identified proteins/peptides (PPs) that were significantly differentially expressed ( < 0.05-ANOVA, MFC (minimum fold change) ≥1.5-) between men and women. The expression profiles of the identified PPs distinctively differentiate women from men using correspondence analysis. The letters in the background are the accession numbers of all the identified PPs in the analysis. (The image was generated using J-express pro V1.1 software program (java.sun.com)). (b) Unsupervised hierarchical cluster analysis of the expression profiles of nondepleted serum samples using 17 PPs that differ significantly ( < 0.05-ANOVA, MFC ≥1.5) between men (blue) and women (red). The dendrogram was generated using the Bray–Curtis correlation distance metric and an average linkage clustering method from the J-express pro V1.1 software program (java.sun.com). Note. One PP (IGHG1) had 2 accession numbers (subtypes of the same PP) are shown in the figure as two different PPs.

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