The Progress of Research on Genetic Factors of Recurrent Pregnancy Loss

Figure 3

Chromosomal inversions: two breaks in the same chromosome, causing the resulting fragments to reconnect after 180 degrees of reversal. (a) Paracentric inversion: the inverted segments do not contain chromosomes. (b) Pericentric inversion: the inverted segments contain chromosomes. (c) Possible gametes of paracentric inversion. In meiosis, a crossover between a normal chromosome and an inverted chromosome results in the loss or duplication of a segment of the gametophyte chromosome, leading to chromosome abnormality and abnormal traits in the offspring. Balanced gametes are designated by the green border. Unbalanced gametes are designated by the red border. (d) Possible gametes of pericentric inversion. Balanced gametes are designated by the green border. Unbalanced gametes are designated by the red border.

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