Identification of Potential Biomarkers of Septic Shock Based on Pathway and Transcriptome Analyses of Immune-Related Genes
Table 1
Correlations between KEGG pathway enrichment score and deconvolution scores for key cells in GSE57065 and GSE95233.
Pathway
Cell type
GSE57065
GSE95233
r
95% CI
r
95%CI
KEGG_ALLOGRAFT_REJECTION
CD4 + TCM
0.56
0.42–0.68
3.26E − 10
0.62
0.50–0.72
1.37E − 14
KEGG_ALLOGRAFT_REJECTION
CD8 + T-cells
0.77
0.68–0.84
6.62E − 22
0.62
0.50–0.72
1.66E − 14
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION
CD4 + TCM
0.41
0.26–0.57
1.45E − 05
0.61
0.49–0.71
3.16E − 14
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION
CD8 + T-cells
0.73
0.64–0.82
4.55E − 19
0.75
0.66–0.82
1.07E − 23
KEGG_AUTOIMMUNE_THYROID_DISEASE
CD4 + TCM
0.47
0.30–0.60
4.03E − 07
0.62
0.50–0.72
1.37E − 14
KEGG_AUTOIMMUNE_THYROID_DISEASE
CD8 + T-cells
0.60
0.46–0.71
8.79E − 12
0.62
0.50–0.72
1.66E − 14
KEGG_CELL_ADHESION_MOLECULES_CAMS
CD4 + TCM
0.55
0.37–0.65
7.21E − 10
0.61
0.49–0.71
3.16E − 14
KEGG_CELL_ADHESION_MOLECULES_CAMS
CD8 + T-cells
0.41
0.24–0.55
1.43E − 05
0.75
0.66–0.82
1.07E − 23
KEGG_GRAFT_VERSUS_HOST_DISEASE
CD4 + TCM
0.54
0.41–0.67
1.34E − 09
0.62
0.50–0.72
1.37E − 14
KEGG_GRAFT_VERSUS_HOST_DISEASE
CD8 + T-cells
0.76
0.68–0.84
2.65E − 21
0.62
0.50–0.72
1.66E − 14
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
CD4 + TCM
0.69
0.60–0.79
1.35E − 16
0.59
0.46–0.70
4.34E − 13
KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION
CD8 + T-cells
0.74
0.66–0.83
1.08E − 19
0.50
0.35–0.62
4.56E − 09
KEGG_PRIMARY_IMMUNODEFICIENCY
CD4 + TCM
0.52
0.38–0.66
7.43E − 09
0.68
0.57–0.76
7.65E − 18
KEGG_PRIMARY_IMMUNODEFICIENCY
CD8 + T-cells
0.83
0.77–0.89
3.70E − 28
0.88
0.83–0.92
1.75E − 41
KEGG_PRIMARY_IMMUNODEFICIENCY
Preadipocytes
0.65
0.52–0.74
2.71E − 14
0.56
0.43–0.67
1.26E − 11
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY
CD8 + T-cells
0.70
0.57–0.78
9.41E − 17
0.87
0.82–0.91
1.08E − 39
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY
Preadipocytes
0.58
0.39–0.66
5.64E − 11
0.48
0.33–0.60
2.20E − 08
KEGG_TYPE_I_DIABETES_MELLITUS
CD4 + TCM
0.52
0.37–0.65
9.03E − 09
0.62
0.50–0.72
1.37E − 14
KEGG_TYPE_I_DIABETES_MELLITUS
CD8 + T-cells
0.72
0.62–0.80
3.83E − 18
0.62
0.50–0.72
1.66E − 14
KEGG_VIRAL_MYOCARDITIS
CD4 + TCM
0.43
0.28–0.58
2.86E − 06
0.62
0.50–0.72
1.37E − 14
KEGG_VIRAL_MYOCARDITIS
CD8 + T-cells
0.55
0.42–0.68
7.63E − 10
0.62
0.50–0.72
1.66E − 14
KEGG, Kyoto Encyclopedia of Genes and Genomes; CI, confidence interval. r indicates the Spearman correlation coefficient. indicates statistical significance.
