HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia

Table 2

Distribution of HLA alleles in CLL patients and the control group.

Allele	Cases n1		Controls n2		value	OR	95% CI
	Number	(%)	Number	(%)			Low	Upper
HLA-A24:02:01	17	12.9	10	5.0	0.01	0.38	0.183	0.822
HLA-DQA105:05:01	29	22.0	24	12.0	0.01	0.56	0.333	0.895
HLA-DQB103:02:01	13	9.8	8	4.0	0.03	0.40	0.173	0.953
HLA-DRB104:02:01	7	5.3	0	0.0	0.001	1.05	1.014	1.100
HLA-DRB302:01:01	5	3.8	0	0.0	0.009	1.03	1.005	1.075
HLA-DRB401:03:01	23	17.4	19	9.5	0.03	0.54	0.309	0.961

Statistical significance was determined after calculating the value, OR (odds ratio), and CI (confidence interval). The chi-square test or Fisher’s test was used to estimate the differences between the CLL patient and control groups; n: number of alleles in the patient and control groups. A complete listing of alleles associated with the disease is provided in Supplemental Tables S1–S4. Comparison of the most important HLA alleles at the 6-digit level between CLL patients and the control group.