Genetics Research

Research Article

HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia

Table 3

Distribution of HLA alleles for males and females in CLL patients and the control group.


Allele	Gender	Cases		Controls		value	OR	95% CI
Allele	Gender	Number	(%)	Number	(%)	value	OR	Low	Upper

HLA-A03:01:01	Female	10	17.8	6	6.5	0.031	0.365	0.140	0.950
HLA-B35:01:01	Female	8	14.2	3	3.2	0.021	0.228	0.063	0.825
HLA-B39:01:01	Female	4	7.14	0	0	0.019	1.077	1.001	1.158
HLA-DQA105:05:01	Female	15	26.7	12	13.04	0.036	0.487	0.246	0.964
HLA-DRB302:01:01	Female	4	7.14	0	0	0.019	1.077	1.001	1.158
HLA-DRB104:02:01	Male	5	6.5	0	0	0.011	1.070	1.008	1.136

Statistical significance was determined after calculating the value, OR (odds ratio), and CI (confidence interval). The chi-square test or Fisher’s test was used to estimate the differences between the CLL patient and control groups; n: number of alleles in the patient and control groups. A complete listing of alleles associated with the disease for each gender is provided in Supplemental Tables S5–S12. Comparison of most important HLA alleles at the 6-digit level between CLL patients and the control group for both genders.