The “CROMa” Project: A Care Pathway for Clinical Management of Patients with Bisphosphonate Exposure

Table 3

Data from CROMa database.

CROMa patients	502
	Males	99
	Females	403
	Age	8–90
	Paediatric	11%
	Adults	89%
		Number
Osteometabolic diseases (OMD)	79% (398)
	Postmenopausal osteoporosis	310
	Osteogenesis imperfecta	54
	Osteopenia	13
	Osteoarthritis	7
	Secondary osteoporosis	6
	Glucocorticoid-induced osteoporosis	3
	Fibrous dysplasia	2
	Paget's disease	1
	Other	2
		Number
Metastatic cancer (CA)	21% (104)
	Prostate cancer bone metastasis	34
	Mammary cancer bone metastasis	28
	Multiple myeloma	14
	Renal cancer bone metastasis	11
	Pulmonary cancer bone metastasis	9
	Other	8
BP administration	BP therapy	58 (11%)
	NBP therapy	444 (89%)
	OS	54%
	IV	31%
	IM	11%
	Association	3%
Patients with no BRONJ		474 (94,42%)
Patients with BRONJ		28 (5,58%)
BRONJ from oral BP		11
BRONJ from IV BP		17