Osteoprotective Effect of Enamel Matrix Derivatives on the Regeneration of Mandibular Defects in Experimentally Glucocorticoid-Induced Osteoporosis

Figure 1

Photomicrograph showing (A1) the bone cavity filled with granulation tissue (arrow head) and the newly formed bone trabeculae (arrow) dispersed in rich highly cellular granulation tissue; (B1) the granulation tissue (arrow head) with severe accumulation of inflammatory cells and dilated blood vessels (curved arrows); (C1) the newly formed bone trabeculae (arrows) parallel to old bone and separated with highly cellular granulation tissue (arrow head); (D1) the newly formed bone trabeculae are anastomosing (arrows) and wide with highly cellular granulation tissue (arrow head); (A2) a net of growing new bony trabeculae (arrow) surrounded by moderately large bone marrow cavities (arrow head); (B2) the beginning of osteoid tissue formation (arrows) still surrounded by highly vascular granulation tissue (arrow head); (C2) the bone cavities were filled with regular bone trabeculae (arrow) formed of large size osteocytes enclosing bone marrow (arrow head); (D2) thick well-organized bone trabeculae (arrow) with osteoblasts lined the large bone marrow spaces (arrow head) (H&E staining ×100).