Salivary Metabolomics of Well and Poorly Controlled Type 1 and Type 2 Diabetes

Table 2

Summary of salivary metabolites differentially expressed in poorly controlled vs. well-controlled type I diabetes.

Metabolite compound ID	VIP	value	Fold change
(1967 peaks)	0.1–2.4	0.001–1	−475, −733.6
(4Z)-4-(3,3-Dimethyltriazanylidene)-4H-imidazole-5-carboxamide	1.4	0.016	1.5
17β-Estradiol 3-benzoate	1.5	0.101	1.4
2-Isopropyl-4a-methyl-8-methylenedecahydro-1-naphthalenol	1.3	0.118	−3.8
2-Methyl-3-ketovaleric acid	1.2	0.302	−1.3
2-Oxo-4-methylthiobutanoic acid	1.4	0.044	1.7
5,6-Dihydrouridine	1.1	0.212	1.3
APGPR enterostatin	1.3	0.173	−2
Androsterone glucuronide	1.1	0.234	2
Coumarin	1.1	0.081	2.7
Cytidine monophosphate N-acetylneuraminic acid	1.4	0.359	−1.6
D-Arginyl-L-arginyl-D-isoleucine	1.1	0.308	−1.3
DG (14:1/25:0/0:0)	1.4	0.177	−1.9
DL-Glutamine	2	0.051	1.2
DL-Asparagine	1.6	0.062	−1.5
Deoxypyridinoline	1.4	0.136	1.5
Dopamine	1	0.91	1
Edoxudine	1.7	0.026	−1.3
GPA (4:0/18:3)	1.6	0.068	1.5
GPSer (9:0/12:0)	1.8	0.049	2.1
Glycyl-phenylalanine	1.2	0.434	1.2
Glycylproline	1.8	0.086	1.3
L-Acetylcarnitine	1.1	0.567	−1.2
L-Proline	1.5	0.105	1.4
N-Acetyl-L-phenylalanine	1.2	0.761	1.1
N-Glycolylneuraminic acid	1.7	0.041	2.7
N6-Acetyl-L-lysine	1	0.766	−1.1
Ne, Ne dimethyllysine	1	0.927	1
PE (24:0/18:2 (9Z,12Z))	1.9	0.044	−2.3
Paramethasone	1.1	0.578	1.2
Salicylic acid	1	0.268	1.7
Stearic acid	1.7	0.037	−1.7
Tyrosyl-proline	1.8	0.015	1.9

t-test with Satterthwaite correction. A positive fold change indicates mean of poorly controlled > mean of well controlled. VIP, variable influence on projection.