International Journal of Dentistry

Review Article

Clinical Efficacy of Platelet Derivatives in Periodontal Tissue Regeneration: An Umbrella Review

Table 2

Primary studies included in the evaluated reviews.


Primary study	Study design	Follow-up in months	Outcome variables	Review including the primary study
Authors	Study design	Follow-up in months	Outcome variables	Miron et al. [17]	Miron et al. [18]	Castro et al. [19]	Panda et al. [20]	Zhou et al. [21]	Moraschini and Barboza [24]	Najeeb et al. [22]	Tavelli et al. [23]

Agarwal et al. [28]	Case control	6	Root coverage CAF versus CAF + AM versus CAF + PRF	X
Agarwal et al. [29]	RCT	12	Intrabody defect regeneration OFD + DFDBA versus OFD + DFDBA + PRF	X	X	X		X		X	X
Agarwal et al. [30]	RCT	12	Intrabody defect regeneration OFD + DFDBA versus OFD + DFDBA + PRP					X			X
Ajwani et al. [31]	RCT	12	Intrabody defect regeneration OFD versus OFD + PRF-L	X	X	X				X	X
Aleksić et al. [32]	RCT	12	Root coverage CAF + CTG versus CAF + PRF	X
Aroca et al. [33]	RCT	6	Root coverage CAF versus CAF + PRF	X		X			X
Atchuta et al. [34]	RCT	6	Intrabody defect regeneration OFD versus OFD + ALLBG + PRF								X
Aydemir Turkal et al. [35]	RCT	6	Intrabody defect regeneration OFD + EMD versus OFD + PRF + EDM		X
Bahammam and Attia [36]	RCT	6	Intrabody defect regeneration OFD + PRF versus OFD + SBG + PRF								X
Bajaj et al. [37]	RCT	9	Furcation degree II OFD versus OFD + PRF-L versus OFD + PRP			X
Bansal and Bharti [38]	RCT	6	Intrabody defect regeneration OFD + DFDBA versus OFD + DFDBA + PRF		X	X		X		X	X
Bodhare et al. [39]	RCT	6	Intrabody defect regeneration OFD + bioguide versus OFD + bioguide +PRF		X						X
Camargo et al. [40]	RCT	9	Intrabody defect regeneration OFD + BPBM versus OFD + PRP + BPBM				X
Chadwick et al. [41]	RCT	6	Intrabody defect regeneration OFD + DFDBA versus OFD + PRF		X						X
Chandradas et al. [42]	RCT	9	Intrabody defect regeneration OFD + PRF versus OFD + XBG + PRF								X
Chatterjee et al. [43]	RCT	9	Intrabody defect regeneration OFD + PRF versus OFD + TPRF (activated in titanium tubes)								X
Demir et al. [44]	RCT	9	Intrabody defect regeneration OFD versus OFD + PRP + SBG								X
Dogan et al. [45]	RCT	6	Root coverage CAF versus CAF + PRF	X
Döri et al. [46]	RCT	12	Intrabody defect regeneration OFD versus OFD + PRF + HA				X				X
Elbehwashy et al. [47]	RCT	6	Intrabody defect regeneration OFD + PRF + ascorbic acid versus OFD + PRF								X
Elgendy and Abo Shady [48]	RCT	6	Intrabody defect regeneration OFD + HA nano bone® versus OFD + PRF-L + nano bone®	X	X	X				X	X
Eren and Atilla [49]	RCT	6	Root coverage CAF + CTG versus CAF + PRF	X		X			X
Galav et al. [50]	RCT	9	Intrabody defect regeneration OFD + BAG versus OFD + PRF		X						X
Gamal et al. [51]	Case control	9	Intrabody defect regeneration OFD + XB versus OFD + PRGF versus OFD + PRF							X	X
Goyal et al. [52]	RCT	12	Intrabody defect regeneration ABBM + GTR + PRP versus ABBM + GTR				X
Gupta et al. [53]	RCT	6	Intrabody defect regeneration OFD + EMD versus OFD + PRF		X	X				X	X
Gupta et al. [54]	RCT	6	Root coverage CAF versus CAF + PRF	X		X
Hanna et al. [55]	RCT	12	Intrabody defect regeneration OFD + HA + sasline versus OFD + PRP + HA				X				X
Harnack et al. [56]	RCT	6	Intrabody defect regeneration OFD versus OFD + PRP								X
Hassan et al. [57]	RCT	12	Intrabody defect regeneration OFD versus OFD + ABG + PRP								X
Hazari et al. [58]	RCT	6	Intrabody defect regeneration OFD versus OFD + SBG + PRF								X
Ilgenli et al. [59]	RCT	6	Intrabody defect regeneration OFD + PRP versus OFD + ABG + PRP								X
Jalaluddin et al. [60]	RCT	6	Intrabody defect regeneration OFD versus OFD + PRP								X
Jalaluddin et al. [61]	RCT	6	Intrabody defect regeneration OFD versus OFD + PRP								X
Jankovic et al. [62]	RCT	9	Root coverage CAF + EMD versus CAF + PRF	X		X			X
Jankovic et al. [63]	RCT	6	Root coverage CAF + CTG versus CAF + PRF	X		X			X
Kang et al. [64]	Case control	6	Intrabody defect regeneration O FD versus OFD + PRP versus OFD + PRF				X
Kanoriya et al. [65]	RCT	9	Intrabody defect regeneration OFD + PRF versus OFD + PRF + Alendronato 1%		X						X
Kaushick et al. [66]	RCT	6	Intrabody defect regeneration OFD versus OFD + SBG + PRP								X
Keceli et al. [67]	RCT	6	Root coverage CAF + CTG versus CAF + CGT + PRF	X		X
Kukreja et al. [68]	RCT	6	Intrabody defect regeneration OFD + DFDBA versus OFD + DFDBA + PRP					X			X
Lekovic et al. [69]	RCT	6	Intrabody defect regeneration OFD + PRF-L versus OFD + PRF-L + BMPM			X	X			X	X
Markou et al. [70]	RCT	6	Intrabody defect regeneration OFD versus OFD + PRP + ABG								X
Martande et al. [71]	RCT	9	Intrabody defect regeneration OFD versus OFD + PRF versus OFD + PRF + Atorvastatina 1.2%		X						X
Mathur et al. [72]	RCT	6	Intrabody defect regeneration OFD + ABG versus OFD + PRF		X	X				X	X
Menezes et al. [73]	RCT	12	Intrabody defect regeneration OFD + DFDBA + PRP versus OFD + DFDBA				X
Naqvi et al. [74]	RCT	9	Intrabody defect regeneration OFD versus OFD + BAG versus OFD + PRF + BAG		X						X
Okuda et al. [75]	Case control	12	Intrabody defect regeneration OFD versus OFD + PRP + SBG								X
Ozdemir and Okte [76]	RCT	6	Intrabody defect regeneration OFD + ABBM versus OFD + PRP + ABBM				X				X
Padma et al. [77]	RCT	6	Root coverage CAF versus CAF + PRF	X		X			X
Panda et al. [78]	RCT	9	Intrabody defect regeneration OFD + barrier membrane versus OFD + barrier membrane + PRF	X
Paolantonio et al. [79]	RCT	12	Intrabody defect regeneration OFD versus OFD + PRF-L + ABG								X
Patel et al. [80]	RCT	12	Intrabody defect regeneration OFD versus OFD + PRF								X
Pavani et al. [81]	RCT	6	Intrabody defect regeneration OFD versus OFD + PRF + SBG								X
Pham [82]	RCT	12	Intrabody defect regeneration OFD + PRF versus GRT versus OFD								X
Pradeep et al. [83]	Case control	9	Effects on intrabody regeneration OFD versus OFD + PRP				X				X
Pradeep et al. [84]	RCT	9	Intrabody defect regeneration OFD versus OFD + PRP versus OFD + PRF-L	X	X	X	X			X	X
Pradeep et al. [85]	RCT	9	Intrabody defect regeneration OFD + 1% MF versus OFD + PRF versus OFD + 1% MF + PRF	X	X	X				X	X
Pradeep et al. [86]	RCT	9	Intrabody defect regeneration OFD versus OFD + PRF + SBG								X
Pradeep et al. [87]	RCT	9	Intrabody defect regeneration OFD versus OFD + PRF versus OFD + PRF + Rosuvastatina 1.2%		X						X
Rajaram et al. [88]	RCT	24	Root coverage DLSBF versus DLSBF + PRF	X
Rosamma et al. [89]	RCT	12	Intrabody defect regeneration OFD versus OFD + PRF-L		X	X
Sezgin et al. [90]	RCT	6	Intrabody defect regeneration OFD versus ABBM + PRP versus OFD + ABBM		X						X
Shah et al. [91]	RCT	6	Intrabody defect regeneration OFD + DFDBA versus OFD + PRF-L	X	X	X				X	X
Sharma and Pradeep [92]	RCT	9	Intrabody defect regeneration OFD versus OFD + PRF	X	X	X	X
Sharma and Pradeep [93]	RCT	9	Furcation degree II OFD + PRF versus OFD + PRF-L	X		X				X	X
Shukla et al. [94]	RCT	9	Intrabody defect regeneration OFD versus OFD + SBG + PRP								X
Thamaraiselvan et al. [95]	Case control	6	Root coverage CAF versus CAF + PRF	X		X			X
Thorat et al. [96]	RCT	9	Intrabody defect regeneration OFD versus OFD + PRF	X	X	X	X			X	X
Tunalɩ et al. [97]	RCT	12	Root coverage CAF + CTG versus CAF + PRF	X		X			X
Yajamanya et al. [98]	RCT	9	Intrabody defect regeneration OFD + BAG versus OFD + PRF		X						X
Yilmaz et al. [99]	RCT	12	Intrabody defect regeneration GTR + BM + PRP versus BM + GTR				X

CAF, coronary displacement flap; EMD, Emdogain; CTG, connective tissue graft; DLSBF, double lateral sliding bridge flap; AM, amniotic membrane; OFD, surgical therapy; DFDBA, demineralized bone matrix; PRP, platelet-rich plasma; L-PRF, leucocyte-and platelet-rich fibrin; MF, metformin; HA, hydroxyapatite; BM, barrier membrane; ABG, autogenous bone graft; BAG, bioactive glass; ABBM, bovine anorganic graft; BMPM, bone morphogenic protein; SBG, synthetic bone graft; PRGF, platelet-derived growth factor; XB, bovine xenograft; BM, bone mineral; ALLBG, allogenic bone graft; RCT, randomized clinical trial.