Review Article

Effectiveness of Cyanoacrylate in the Treatment of Dentin Hypersensitivity: A Systematic Review

Table 2

Characteristics of selected studies.

Author/Year/Country/Study designSample sizeInterventions/protocolsEvaluations/follow-upFindings

Flecha et al., [18, 24]/Brazil/RCT, Double-blind, split-mouth434 TeethTG - Super Bonder®
CG - LLLT
Protocol: 3x 48/48 hs
NRS:
- Air spray = 4s
- Tetrafluormethan spray (Endo Ice®) = 4s
Baseline, 24 hr, 30, 90, and 180 days
Reduction in DH ≠ a significant.
Within 24 hr better results were recorded for cyanoacrylate

Flecha et al., [18, 24]/Brazil/RCT, Double-blind, split-mouth -Pilot study34 HemiarchTG - Super Bonder®
CG - LLLT
Protocol: 3x 48/48 hs
NRS:
- Air spray = 5s
- Tetrafluormethan spray (Endo Ice®) = 5s
Baseline, 24 hr, 30, and 120 days
TG = Endo-Ice: 24 hr ≠ significant
TG = Air blast: 120 days ≠ significant
CG = Endo-Ice: 120 days ≠ significant

Naregal and Raju [27]/Índia/NRCT45 Teeth
15 Patients
G1 (CG) = Distilled water G2 = Potassium oxalate 30%
G3—N-butyl 2-cyanoacrylate
Protocol: 1 min
VAS:
- Tactile stimuli
- Electrical stimulation
Baseline, immediate and once a week for
12 weeks
Tactile stimulus:
G2 and G3 = ≠ significant 7 weeks
G2 = w/o DH until end
Electrical stimulation:
G2 and G3 = ≠ significant 6 weeks
G3 = > DH reduction

de la Caridad Perez-Alvarez et al. [17]/Cuba/NRCT152 Patients- Chlorhexidine 0,2% = 1 min
- Tisuacryl® = 60s
Pain evaluation:
Level 1 = absence
Level 2 = pain remains
2, 4, 5 e 6 days after intervention
Treatment with Tisuacryl:
was successful in 96.7% of patients:
Severe DH = 81.5%
Light/moderate = 100%

Santos et al. [25]/Brazil/NRCT655 Teeth
73 Patients
G1: Super Bonder® = 1
G2: Prime & Bond 2.1 = 1
G3: Super Bonder® = 4
G4: Prime & Bond 2.1 = 4
- Mechanical stimuli = exploratory probe n 5
- Thermal stimuli = air spray/Endo Ice®
Baseline, weekly, and 60 days
Groups 3 and 4:
statistically significant results in DH reduction

Guimarães [26]/Brazil/NRCT60 Teeth
23 Patients
G1: Fluorniz® = 4
G2: Super Bonder® = 1
- Mechanical stimuli = exploratory probe
- Thermal stimuli = water spray/air spray
7/7 days - 3 weeks
Super Bonder® Group:
93.3% - DH reduction
Fluorniz® Group:
90% - DH reduction

Javid et al. [28]/Iran/NRCT60 PatientsG1: NaF 33% = 6
G2: cyanoacrylate = 1
- Air spray for 1s
24 hr and weekly (6x)
Cyanoacrylate group:
25 = immediate and continuous relief.
Fluoride Group:
21 = had lower scores than initial

Note. Table template font: Belém et al. [23]. Abbreviations: CG, control group; DH, dentin hypersensitivity; LLLT, low-level laser therapy; NaF, sodium fluoride; NRCT, nonrandomized clinical trial; NRS, Numerical Rating Scale; RCT, randomized clinical trial; TG, test group; VAS, Visual Analoge Scale.