Novel Herbal Therapeutic YH23537 Improves Clinical Parameters in Ligature-Induced Periodontal Disease Model in Beagle Dogs

Figure 5

Clinical attachment level (CAL) in ligature-induced periodontitis dogs. The left upper second premolar (PM2), third premolar (PM3), and fourth premolar (PM4) as well as the left lower PM3, PM4, and first molar (M1) were ligated with silk-wire twisted ligatures and the dogs were fed with soft moistened food. After 8 weeks, the ligatures were removed and the dogs were administered with YH23537 or YH14642 for 4 weeks. CAL was measured at every week throughout the experimental period ((a) week 1; (b) week 2; (c) week 3; (d) week 4). Data represent the mean ± SD. , , and compared with the placebo group.

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